Prof. Dr. med. Joachim Wölfle

Publikationen 2007

  • Melichar VO, Guth S, Hellebrand H, Meindl A, von der Hardt K, Kraus C, Trautmann U, Rascher W, Rauch A, Zenker M (2007) A male infant with a 9.6 Mb terminal Xp deletion including the OA1 locus: Limit of viability of Xp deletions in males. Am. J. Med. Genet. A. 143(2): 135-141
  • Utsch B, McCabe CD, Galbraith K, Gonzalez R, Born M, Dötsch J, Ludwig M, Reutter H, Innis JW (2007) Molecular characterization of HOXA13 polyalanine expansion proteins in hand-foot-genital syndrome. Am. J. Med. Genet. A. 143(24): 3161-3168
  • Knerr I, Gibson KM, Ganesh J, Bennett MJ, Salomons GS, Jakobs C, Myers SM (2007) Diagnostic challenges in a severely delayed infant with hypersomnolence, failure to thrive and arteriopathy: A unique case of gamma-hydroxybutyric aciduria and Williams syndrome. Am. J. Med. Genet. B. Neuropsychiatr. Genet. 144B(7): 946-948
  • Rauch A, Dörr HG (2007) Chromosome 5q subtelomeric deletion syndrome. Am. J. Med. Genet. C. Semin. Med. Genet. 145C(4): 372-376
  • Struwe E, Berzl GM, Schild RL, Beckmann MW, Dörr HG, Rascher W, Dötsch J (2007) Simultaneously reduced gene expression of cortisol-activating and cortisol-inactivating enzymes in placentas of small-for-gestational-age neonates. Am. J. Obstet. Gynecol. 197(1): 43.e1-6
  • Trollmann R, Klingmüller K, Schild RL, Rascher W, Dötsch J (2007) Differential gene expression of somatotrophic and growth factors in response to in vivo hypoxia in human placenta. Am. J. Obstet. Gynecol. 197(6): 601.e1-6
  • Köhler H, Sakaguchi T, Hurley BP, Kase BA, Kase BJ, Reinecker HC, McCormick BA (2007) Salmonella enterica serovar Typhimurium regulates intercellular junction proteins and facilitates transepithelial neutrophil and bacterial passage. Am. J. Physiol. Gastrointest. Liver Physiol. 293(1): G178-87
  • Alejandre-Alcázar MA, Kwapiszewska G, Reiss I, Amarie OV, Marsh LM, Sevilla-Pérez J, Wygrecka M, Eul B, Köbrich S, Hesse M, Schermuly RT, Seeger W, Eickelberg O, Morty RE (2007) Hyperoxia modulates TGF-beta/BMP signaling in a mouse model of bronchopulmonary dysplasia. Am. J. Physiol. Lung Cell Mol. Physiol. 292(2): L537-49
  • Hartner A, Cordasic N, Klanke B, Wittmann M, Veelken R, Hilgers KF (2007) Renal injury in streptozotocin-diabetic Ren2-transgenic rats is mainly dependent on hypertension, not on diabetes. Am. J. Physiol. Renal Physiol. 292(2): F820-7
  • Weigel C, Rauh M, Kiener C, Rascher W, Knerr I (2007) Effects of various dietary amino acid preparations for phenylketonuric patients on the metabolic profiles along with postpran-dial insulin and ghrelin responses. Ann. Nutr. Metab. 51(4): 352-358
  • Knerr I, Schnare M, Hermann K, Kausler S, Lehner M, Vogler T, Rascher W, Meissner U (2007) Fusiogenic endogenous-retroviral syncytin-1 exerts anti-apoptotic functions in staurosporine-challenged CHO cells. Apoptosis 12(1): 37-43
  • Gagel B, Piroth M, Pinkawa M, Reinartz P, Krohn T, Kaiser HJ, Stanzel S, Breuer C, Asadpour B, Schmachtenberg A, Eble MJ (2007) Sequential (gemcitabine/vinorelbine) and concurrent (gemcitabine) radiochemotherapy with FDG-PET-based target volume definition in locally advanced non-small cell lung cancer: first results of a phase I/II study. BMC Cancer. 7: 112
  • Meisel R, Kuypers L, Dirksen U, Schubert R, Gruhn B, Strauss G, Beutel K, Groll AH, Duffner U, Blütters-Sawatzki R, Holter W, Feuchtinger T, Grüttner HP, Schroten H, Zielen S, Ohmann C, Laws HJ, Dilloo D, Impfung von Kindern nach allogener Stammzelltransplantation (IKAST) Study Group (2007) Pneumococcal conjugate vaccine provides early protective antibody responses in children after related and unrelated allogeneic hematopoietic stem cell transplantation. Blood 109(6): 2322-2326
  • Lehner M, Bailo M, Roesler W, Stachel D, Parolini O, Holter W (2007) Apoptosis induction in malignant myeloid cells. Bone Marrow Transplant. 39 Suppl.: S313-S313
  • Strahm B, Locatelli F, Bader P, Ehlert K, Kremens B, Zintl F, Führer M, Stachel D, Sykora KW, Sedlacek P, Baumann I, Niemeyer CM (2007) Reduced intensity conditioning in unrelated donor transplantation for refractory cytopenia in childhood. Bone Marrow Transplant. 40(4): 329-333
  • Kraus C, Reis A, Naehrlich L, Dötsch J, Korbmacher C, Rauh R (2007) Functional characterization of a novel CFTR mutation P67S identified in a patient with atypical cystic fibrosis. Cell Physiol. Biochem. 19(5-6): 239-248
  • Rauh M, Gröschl M, Rascher W (2007) Simultaneous quantification of ghrelin and desacyl-ghrelin by liquid chromatography-tandem mass spectrometry in plasma, serum, and cell supernatants. Clin. Chem. 53(5): 902-910
  • Nüsken KD, Nüsken E, Petrasch M, Rauh M, Dötsch J (2007) Preanalytical influences on the measurement of visfatin by enzyme immuno assay. Clin. Chim. Acta 382(1-2): 154-156
  • Paulides M, Dörr HG, Stöhr W, Bielack S, Koscielniak E, Klingebiel T, Jürgens H, Bölling T, Willich N, Sauer R, Langer T, Beck JD, Late Effects Surveillance System (2007) Thyroid function in paediatric and young adult patients after sarcoma therapy: a report from the Late Effects Surveillance System. Clin. Endocrinol. (Oxf). 66(5): 727-731
  • Plank C, Meissner U, Rauh M, Wollmann H, Dörr HG, Rascher W, Dötsch J (2007) Cortisol-cortisone ratios in small for gestational age (SGA) children without postnatal catch-up growth. Clin. Endocrinol. (Oxf). 67(2): 304-309
  • Benz K, Nauck MA, Böhler J, Fischer KG (2007) Hemofiltration of recombinant hirudin by different hemodialyzer membranes: implications for clinical use. Clin. J. Am. Soc. 2(3): 470-476
  • Benz K, Amann K, Dittrich K, Hugo C, Schnur K, Dötsch J (2007) Patient with antibody-negative relapse of Goodpasture syndrome. Clin. Nephrol. 67(4): 240-244
  • Dohnal AM, Witt V, Hügel H, Holter W, Gadner H, Felzmann T (2007) Phase I study of tumor Ag-loaded IL-12 secreting semi-mature DC for the treatment of pediatric cancer. Cytotherapy 9(8): 755-770
  • Alejandre-Alcázar MA, Shalamanov PD, Amarie OV, Sevilla-Pérez J, Seeger W, Eickelberg O, Morty RE (2007) Temporal and spatial regulation of bone morphogenetic protein signaling in late lung development. Dev. Dyn. 236(10): 2825-2835
  • Knerr I, Hofer SE, Holterhus PM, Näke A, Rosenbauer J, Weitzel D, Wolf J, Holl RW (2007) Prevailing therapeutic regimes and predictive factors for prandial insulin substitution in 26687 children and adolescents with Type 1 diabetes in Germany and Austria. Diabet. Med. 24(12): 1478-1481
  • Köhler H, Zink S, Scharf J, Koch A (2007) Severe esophageal burn after transesophageal pacing. Endoscopy 39(S 1): E300
  • Köhler H, Razeghi S, Spychalski N, Behrens R, Carbon R (2007) Laparoscopic-assisted percutaneous endoscopic gastrostomy - rendez-vous PEG - in infants, children and adolescents. Endoscopy 39(S 1): E136
  • Brun-Heath I, Lia-Baldini AS, Maillard S, Taillandier A, Utsch B, Nunes ME, Serre JL, Mornet E (2007) Delayed transport of tissue-nonspecific alkaline phosphatase with missense mutations causing hypophosphatasia. Eur. J. Med. Genet. 50(5): 367-378
  • Rohrer T, Stierkorb E, Grabert M, Holterhus PM, Kapellen T, Knerr I, Mix M, Holl RW, on behalf of the DPV Initiative (2007) Delayed menarche in young German women with type 1 diabetes mellitus: recent results from the DPV diabetes documentation and quality management system. Eur. J. Pediatr.
  • Sauerstein K, Schroth M, Amann K, Hoyer J, Singer H, Rauch A, Dötsch J (2007) Pulmonary embolism-a rare complication of Schimke immunoosseous dysplasia. Eur. J. Pediatr. 166(12): 1285-1288
  • Buderus S, Utsch B, Huebner A, Lentze MJ, Roth C (2007) Dysphagia due to triple A syndrome: successful treatment of achalasia by balloon dilatation. Exp. Clin. Endocrinol. Diabetes 115(8): 533-536
  • Dörr HG (2007) Growth in patients with classic congenital adrenal hyperplasia due to 21-hydroxylase deficiency. Horm. Res. 68 Suppl 5: 93-99
  • Gagel B, Demirel C, Kientopf A, Pinkawa M, Piroth M, Stanzel S, Breuer C, Asadpour B, Jansen T, Holy R, Wildberger JE, Eble MJ (2007) Active breathing control (ABC): determination and reduction of breathing-induced organ motion in the chest. Int. J. Radiat. Oncol. Biol. Phys. 67(3): 742-749
  • Hoefele J, Wolf MT, O'Toole JF, Otto EA, Schultheiss U, Dêschenes G, Attanasio M, Utsch B, Antignac C, Hildebrandt F (2007) Evidence of oligogenic inheritance in nephronophthisis. J. Am. Soc. Nephrol. 18(10): 2789-2795
  • Karges B, Muche R, Knerr I, Ertelt W, Wiesel T, Hub R, Neu A, Klinghammer A, Aufschild J, Rapp A, Schirbel A, Boehm BO, Debatin KM, Heinze E, Karges W (2007) Levothyroxine in euthyroid autoimmune thyroiditis and type 1 diabetes: a randomized, controlled trial. J. Clin. Endocrinol. Metab. 92(5): 1647-1652
  • Song L, Alcalai R, Arad M, Wolf CM, Toka O, Conner DA, Berul CI, Eldar M, Seidman CE, Seidman JG (2007) Calsequestrin 2 (CASQ2) mutations increase expression of calreticulin and ryanodine receptors, causing catecholaminergic polymorphic ventricular tachycardia. J. Clin. Invest. 117(7): 1814-1823
  • Nüsken KD, Warnecke C, Hilgers KF, Schneider H (2007) Intrauterine growth after uterine artery ligation in rats: dependence on the fetal position in the uterine horn and need for prenatal marking of the animals. J. Hypertens. 25(1): 247-248
  • Lehner M, Morhart P, Stilper A, Petermann D, Weller P, Stachel D, Holter W (2007) Efficient chemokine-dependent migration and primary and secondary IL-12 secretion by human dendritic cells stimulated through Toll-like receptors. J. Immunother. 30(3): 312-322
  • Knerr I, Pearl PL, Bottiglieri T, Snead OC, Jakobs C, Gibson KM (2007) Therapeutic concepts in succinate semialdehyde dehydrogenase (SSADH; ALDH5a1) deficiency (gamma-hydroxybutyric aciduria). Hypotheses evolved from 25 years of patient evaluation, studies in Aldh5a1-/- mice and characterization of gamma-hydroxybutyric acid. J. Inherit. Metab. Dis. 30(3): 279-294
  • Helou J, Otto EA, Attanasio M, Allen SJ, Parisi MA, Glass I, Utsch B, Hashmi S, Fazzi E, Omran H, O'Toole JF, Sayer JA, Hildebrandt F (2007) Mutation analysis of NPHP6/CEP290 in patients with Joubert syndrome and Senior-Løken syndrome. J. Med. Genet. 44(10): 657-663
  • Zenker M, Horn D, Wieczorek D, Allanson J, Pauli S, van der Burgt I, Doerr HG, Gaspar H, Hofbeck M, Gillessen-Kaesbach G, Koch A, Meinecke P, Mundlos S, Nowka A, Rauch A, Reif S, von Schnakenburg C, Seidel H, Wehner LE, Zweier C, Bauhuber S, Matejas V, Kratz CP, Thomas C, Kutsche K (2007) SOS1 is the second most common Noonan gene but plays no major role in cardio-facio-cutaneous syndrome. J. Med. Genet. 44(10): 651-656
  • Rosseneu S, Afzal N, Yerushalmi B, Ibarguen-Secchia E, Lewindon P, Cameron D, Mahler T, Schwagten K, Köhler H, Lindley KJ, Thomson M (2007) Topical application of mitomycin-C in oesophageal strictures. J. Pediatr. Gastroenterol. Nutr. 44(3): 336-341
  • Benz K, Orth SR, Simonaviciene A, Linz W, Schindler U, Rutten H, Amann K (2007) Blood pressure-independent effect of long-term treatment with the soluble heme-independent guanylyl cyclase activator HMR1766 on progression in a model of noninflammatory chronic renal damage. Kidney Blood Press. Res. 30(4): 224-233
  • Bölling T, Schuck A, Pape H, Rübe C, Meyer FM, Martini C, Timmermann B, Asadpour B, Kortmann RD, Beck JD, Langer T, Paulides M, Könemann S, Willich N (2007) [Register for the evaluation of side effects after radiation in childhood and adolescence--first results] Klin. Pädiatr. 219(3): 139-145
  • Naehrlich L (2007) [Sweat testing practices in German cystic fibrosis centres] Klin. Pädiatr. 219(2): 70-73
  • Sauerstein K, Zimmermann B, Benz K, Dittrich K, Rascher W, Dötsch J (2007) Encouraging survival of infants with terminal renal failure combining dialysis and succeeding early transplantation. Klin. Pädiatr. 219(5): 288-291
  • Lehner M, Bailo M, Stachel D, Roesler W, Parolini O, Holter W (2007) Caspase-8 dependent apoptosis induction in malignant myeloid cells by TLR stimulation in the presence of IFN-alpha. Leuk. Res. 31(12): 1729-1735
  • Metzler M, Bruch J, Stachel D, Langer T, Borkhardt A, Harbott J, Rascher W, Holter W (2007) Temporary blast reduction after immunoglobulin administration for congenital cytomegalovirus infection masking infant leukemia with cryptic MLL rearrangement. Leuk. Res. 31(4): 553-557
  • Schwemmlein M, Stieglmaier J, Kellner C, Peipp M, Saul D, Oduncu F, Emmerich B, Stockmeyer B, Lang P, Beck JD, Fey GH (2007) A CD19-specific single-chain immunotoxin mediates potent apoptosis of B-lineage leukemic cells. Leukemia 21(7): 1405-1412
  • Prunier AL, Schuch R, Fernández RE, Mumy KL, Kohler H, McCormick BA, Maurelli AT (2007) nadA and nadB of Shigella flexneri 5a are antivirulence loci responsible for the synthesis of quinolinate, a small molecule inhibitor of Shigella pathogenicity. Microbiology 153(Pt 7): 2363-2372
  • Stachel D, Albert M, Meilbeck R, Paulides M, Schmid I (2007) Expression of angiogenic factors in childhood B-cell precursor acute lymphoblastic leukemia. Oncol. Rep. 17(1): 147-152
  • Langer T, Deeg KH, Hümmer P, Paulides M, Beck JD, Klinge J (2007) Postnatal respiratory distress in a dichorial twin with congenital thoracic neuroblastoma after assisted reproduction by intracytoplasmatic sperm injection. Pediatr. Blood Cancer 48(3): 358-360
  • Stöhr W, Patzer L, Paulides M, Kremers A, Beck JD, Langer T, Rossi R (2007) Growth impairment after ifosfamide-induced nephrotoxicity in children. Pediatr. Blood Cancer 48(5): 571-576
  • Stöhr W, Paulides M, Bielack S, Jürgens H, Koscielniak E, Rossi R, Langer T, Beck JD (2007) Nephrotoxicity of cisplatin and carboplatin in sarcoma patients: a report from the late effects surveillance system. Pediatr. Blood Cancer 48(2): 140-147
  • Stöhr W, Paulides M, Bielack S, Jürgens H, Treuner J, Rossi R, Langer T, Beck JD (2007) Ifosfamide-induced nephrotoxicity in 593 sarcoma patients: a report from the Late Effects Surveillance System. Pediatr. Blood Cancer 48(4): 447-452
  • Hartwig M, Weigel S, Bernig T, Bader P, Dölken R, Beck J (2007) Maintenance immunotherapy by repetitive low-dose donor lymphocytes infusions in a child with relapse state AML after allogeneic stem cell transplantation. Pediatr. Hematol. Oncol. 24(2): 137-140
  • Krappmann P, Paulides M, Stöhr W, Ittner E, Plattig B, Nickel P, Lackner H, Schrappe M, Janka G, Beck JD, Langer T (2007) Almost normal cognitive function in patients during therapy for childhood acute lymphoblastic leukemia without cranial irra-diation according to ALL-BFM 95 and COALL 06-97 protocols: results of an Austrian-German multicenter longitudinal study and implications for follow-up. Pediatr. Hematol. Oncol. 24(2): 101-109
  • Benz K, Amann K, Dittrich K, Dötsch J (2007) Thrombotic microangiopathy as a complication in a patient with focal segmental glomerulosclerosis. Pediatr. Nephrol. 22(12): 2125-2128
  • Gbadegesin R, Hinkes B, Vlangos C, Mucha B, Liu J, Hopcian J, Hildebrandt F (2007) Mutational analysis of NPHS2 and WT1 in frequently relapsing and steroid-dependent nephrotic syndrome. Pediatr. Nephrol. 22(4): 509-513
  • Plank C, Ostreicher I, Dittrich K, Waldherr R, Voigt M, Amann K, Rascher W, Dötsch J (2007) Low birth weight, but not postnatal weight gain, aggravates the course of nephrotic syndrome. Pediatr. Nephrol. 22(11): 1881-1889
  • Hinkes BG, Mucha B, Vlangos CN, Gbadegesin R, Liu J, Hasselbacher K, Hangan D, Ozaltin F, Zenker M, Hildebrandt F (2007) Nephrotic syndrome in the first year of life: two thirds of cases are caused by mutations in 4 genes (NPHS1, NPHS2, WT1, and LAMB2). Pediatrics 119(4): e907-19
  • Adamietz B, Cavallaro A, Radkow T, Alibek S, Holter W, Bautz WA, Staatz G (2007) [Tolerance of magnetic resonance imaging in children and adolescents performed in a 1.5 Tesla MR scanner with an open de-sign] Rofo. 179(8): 826-831
  • Bolling T, Schuck A, Pape H, Rube C, Meyer FM, Martini C, Timmermann B, Asadpour B, Kortmann RD, Beck JD, Langer T, Paulides M, Willich N (2007) German register for detection of late sequelae after radiotherapy for children and adolescents (RiSK): Present status and first results. Strahlenther. Onkol. 183 Suppl.: 7-8
  • Ringwald J, Schroth M, Faschingbauer F, Strobel J, Strasser E, Schild RL, Goecke TW (2007) Intrauterine use of hyperconcentrated platelet concentrates collected with Trima Accel in a case of neonatal alloimmune thrombocytopenia. Transfusion 47(8): 1488-1493
  • Jungraithmayr TC, Wiesmayr S, Staskewitz A, Kirste G, Bulla M, Fehrenbach H, Dippell J, Greiner C, Griebel M, Helmchen U, Klaus G, Leichter HE, Mihatsch MJ, Michalk DV, Misselwitz J, Plank C, Tönshoff B, Weber LT, Zimmer-hackl LB, German Pediatric Renal Transplantation Study Group (2007) Five-year outcome in pediatric patients with mycophenolate mofetil-based renal transplantation. Transplantation 83(7): 900-905
  • Deeg KH, Dachert C, Glöckel U, Langer T (2007) The different features of congenital neuroblastomas: report about the sonographic diagnosis of three cases. Ultraschall Med. 28(3): 313-320
  • Fröhlich T, Greess H, Köhler H (2007) [Topical mitomycin C treatment of a benign oesophageal stricture following caustic ingestion in a four-year-old boy] Z. Gastroenterol. 45(3): 255-258

Publikationen 2008

  • Simon A, Ammann RA, Bode U, Fleischhack G, Wenchel HM, Schwamborn D, Gravou C, Schlegel PG, Rutkowski S, Dannenberg C, Körholz D, Laws HJ, Kramer MH (2008) Healthcare-associated infections in pediatric cancer patients: results of a prospective surveillance study from university hospitals in Germany and Switzerland. BMC Infect Dis. 8: 70
  • Arenz S, Nennstiel-Ratzel U, Wildner M, Dörr HG, von Kries R (2008) Intellectual outcome, motor skills and BMI of children with congenital hypothyroidism: a population-based study. Acta Paediatr. 97: 447-450
  • Sherman EA, Strauss KA, Tortorelli S, Bennett MJ, Knerr I, Morton DH, Puffenberger EG (2008) Genetic mapping of glutaric aciduria, type 3, to chromosome 7 and identification of mutations in c7orf10. Am. J. Hum. Genet. 83: 604-609
  • Hartner A, Marek I, Cordasic N, Haas C, Schocklmann H, Hulsmann-Volkert G, Plasa I, Rascher W, Hilgers KF, Amann K (2008) Glomerular regeneration is delayed in nephritic alpha 8-integrin-deficient mice: contribution of alpha 8-integrin to the regulation of mesangial cell apoptosis. Am. J. Nephrol. 28: 168-178
  • Trollmann R, Strasser K, Keller S, Antoniou X, Grenacher B, Ogunshola OO, Dötsch J, Rascher W, Gassmann M (2008) Placental HIFs as markers of cerebral hypoxic distress in fetal mice. Am. J. Physiol. Regul. Integr. Comp. Physiol. 295: R1973-81
  • Weigel C, Kiener C, Meier N, Schmid P, Rauh M, Rascher W, Knerr I (2008) Carnitine status in early-treated children, adolescents and young adults with phenylketonuria on low phenylalanine diets. Ann. Nutr. Metab. 53: 91-95
  • Gelse K, Mühle C, Franke O, Park J, Jehle M, Durst K, Göken M, Hennig F, Mark KV, Schneider H (2008) Cell-based resurfacing of large cartilage defects: Long-term evaluation of grafts from autologous transgene-activated periosteal cells in a porcine model of osteoarthritis. Arthritis Rheum. 58: 475-488
  • Schmid I, Stachel D, Pagel P, Albert MH (2008) Incidence, predisposing factors, and outcome of engraftment syndrome in pediatric allogeneic stem cell transplant recipients. Biol. Blood Marrow Transplant. 14: 438-444
  • Möricke A, Reiter A, Zimmermann M, Gadner H, Stanulla M, Dördelmann M, Löning L, Beier R, Ludwig WD, Ratei R, Harbott J, Boos J, Mann G, Niggli F, Feldges A, Henze G, Welte K, Beck JD, Klingebiel T, Niemeyer C, Zintl F, Bode U, Urban C, Wehinger H, Niethammer D, Riehm H, Schrappe M, German-Austrian-Swiss ALL-BFM Study Group (2008) Risk-adjusted therapy of acute lymphoblastic leukemia can decrease treatment burden and improve survival: treatment results of 2169 unselected pediatric and adolescent patients enrolled in the trial ALL-BFM 95. Blood 111: 4477-4489
  • Trollmann R, Schneider J, Keller S, Strasser K, Wenzel D, Rascher W, Ogunshola OO, Gassmann M (2008) HIF-1-regulated vasoactive systems are differentially involved in acute hypoxic stress responses of the developing brain of newborn mice and are not affected by levetiracetam. Brain Res. 1199: 27-36
  • Knerr I, Gibson KM, Jakobs C, Pearl PL (2008) Neuropsychiatric morbidity in adolescent and adult succinic semialdehyde dehydrogenase deficiency patients. CNS Spectr. 13: 598-605
  • Völkl T, Ogilvie A, Neuhuber W, Ogilvie A (2008) Cell death induced by uridine 5'-triphosphate (UTP) in contrast to adenosine 5'-triphosphate (ATP) in human epidermoid carcinoma cells (A-431). Cell Physiol. Biochem. 22: 441-454
  • Röbl M, Knerr I, Keller KM, Jaeschke R, Hoffmeister U, Reinehr T, Holl RW (2008) Obesity in children and adolescents and their parents. Correlation of standardized body mass index between patients, their parents and siblings from the multicentre APS data. Dtsch. Med. Wochenschr. 133: 2448-2453
  • Köhler H, Lang T, Behrens R (2008) Buried bumper syndrome after percutaneous endoscopic gastrostomy in children and adolescents. Endoscopy 40 Suppl 2: E85-86
  • Bani Hashemi S, Braun J, Bernhardt WM, Rascher W, Dötsch J, Trollmann R (2008) HIF-1alpha subunit and vasoactive HIF-1-dependent genes are involved in carbon monoxide-induced cerebral hypoxic stress response. Eur. J. Appl. Physiol. 104: 95-102
  • Zopf Y, Rabe C, Neubert A, Gassmann KG, Rascher W, Hahn EG, Brune K, Dormann H (2008) Women encounter ADRs more often than do men. Eur. J. Clin. Pharmacol. 64: 999-1004
  • Thiel CT, Dörr HG, Trautmann U, Hoyer J, Hofmann K, Kraus C, Ekici AB, Reis A, Rauch A (2008) A de novo 7.6Mb tandem duplication of 14q32.2-qter associated with primordial short stature with neurosecretory growth hormone dysfunction, distinct facial anomalies and mild developmental delay. Eur. J. Med. Genet. 51: 362-367
  • Rohrer T, Stierkorb E, Grabert M, Holterhus PM, Kapellen T, Knerr I, Mix M, Holl RW, DPV Initiative (2008) Delayed menarche in young German women with type 1 diabetes mellitus: recent results from the DPV diabetes documentation and quality management system. Eur. J. Pediatr. 167: 793-799
  • Park J, Will C, Martin B, Gullotti L, Friedrichs N, Buettner R, Schneider H, Ludwig S, Wixler V (2008) Deficiency in the LIM-only protein FHL2 impairs assembly of extracellular matrix proteins. FASEB J. 22: 2508-2520
  • Plank C, Grillhösl C, Östreicher I, Meissner U, Struwe FG, Rauh M, Hartner A, Rascher W, Dötsch J (2008) Transient growth hormone therapy to rats with low protein-inflicted intrauterine growth restriction does not prevent elevated blood pressure in later life. Growth Factors 26: 355-364
  • Hinkmann C, Knerr I, Hahn EG, Lohmann T, Seifarth CC (2008) Reduced frequency of peripheral plasmacytoid dendritic cells in type 1 diabetes. Horm. Metab. Res. 40: 767-771
  • Spranger RM, Hartner A, Schild RL, Stuppy A, Knerr I, Rascher W, Dötsch J (2008) Leptin expression in primary trophoblast cells in response to incubation with the serum of preeclamptic women. Hypertens. Pregnancy 27: 267-277
  • Muller DN, Klanke B, Feldt S, Cordasic N, Hartner A, Schmieder RE, Luft FC, Hilgers KF (2008) (Pro)renin receptor peptide inhibitor "handle-region" peptide does not affect hypertensive nephrosclerosis in goldblatt rats. Hypertension 51: 676-681
  • Westhoff JH, Hilgers KF, Steinbach MP, Hartner A, Klanke B, Amann K, Melk A (2008) Hypertension induces somatic cellular senescence in rats and humans by induction of cell cycle inhibitor p16INK4a. Hypertension 52: 123-129
  • Dittrich K, Richter M, Rascher W, Köhler H (2008) Leukocytapheresis in a girl with severe ulcerative colitis refractory to corticosteroids, infliximab, and cyclosporine A. Inflamm. Bowel Dis. 14: 1466-1467
  • Hinkes B, Vlangos C, Heeringa S, Mucha B, Gbadegesin R, Liu J, Hasselbacher K, Ozaltin F, Hildebrandt F, APN Study Group (2008) Specific podocin mutations correlate with age of onset in steroid-resistant nephrotic syndrome. J. Am. Soc. Nephrol. 19: 365-371
  • Konrad M, Hou J, Weber S, Dötsch J, Kari JA, Seeman T, Kuwertz-Bröking E, Peco-Antic A, Tasic V, Dittrich K, Alshaya HO, von Vigier RO, Gallati S, Goodenough DA, Schaller A (2008) CLDN16 genotype predicts renal decline in familial hypomagnesemia with hypercalciuria and nephrocalcinosis. J. Am. Soc. Nephrol. 19: 171-181
  • Veelken R, Vogel EM, Hilgers K, Amann K, Hartner A, Sass G, Neuhuber W, Tiegs G (2008) Autonomic renal denervation ameliorates experimental glomerulonephritis. J. Am. Soc. Nephrol. 19: 1371-1378
  • Schrauder M, Frank S, Strissel PL, Lux MP, Bani MR, Rauh C, Sieber CC, Heusinger K, Hartmann A, Schulz-Wendtland R, Strick R, Beckmann MW, Fasching PA (2008) Single nucleotide polymorphism D1853N of the ATM gene may alter the risk for breast cancer. J. Cancer Res. Clin. Oncol. 134: 873-882
  • Knerr I, Söder S, Licha E, Aigner T, Rascher W (2008) Response of HEK293 and CHO cells overexpressing fusiogenic syncytin-1 to mitochondrion-mediated apoptosis induced by antimycin A. J. Cell. Biochem. 105: 766-775
  • Welzel M, Wüstemann N, Simic-Schleicher G, Dörr HG, Schulze E, Shaikh G, Clayton P, Grötzinger J, Holterhus PM, Riepe FG (2008) Carboxyl-terminal mutations in 3beta-hydroxysteroid dehydrogenase type II cause severe salt-wasting congenital adrenal hyperplasia. J. Clin. Endocrinol. Metab. 93: 1418-1425
  • Lehner M, Stilper A, Morhart P, Holter W (2008) Plasticity of dendritic cell function in response to prostaglandin E2 (PGE2) and interferon-gamma (IFN-gamma). J. Leukoc. Biol. 83: 883-893
  • Lobato MN, Metzler M, Drynan L, Forster A, Pannell R, Rabbitts TH (2008) Modeling chromosomal translocations using conditional alleles to recapitulate initiating events in human leukemias. J. Natl. Cancer Inst. Monogr. 39: 58-63
  • Weigel C, Kokocinski K, Lederer P, Dötsch J, Rascher W, Knerr I (2008) Childhood obesity: concept, feasibility, and interim results of a local group-based, long-term treatment program. J. Nutr. Educ. Behav. 40: 369-373
  • Fröhlich T, Otto S, Weber P, Pilic D, Schmidt-Choudhury A, Wenzl TG, Köhler H (2008) Combined esophageal multichannel intraluminal impedance and pH monitoring after repair of esophageal atresia. J. Pediatr. Gastroenterol. Nutr. 47: 443-449
  • Gröschl M, Köhler H, Topf HG, Rupprecht T, Rauh M (2008) Evaluation of saliva collection devices for the analysis of steroids, peptides and therapeutic drugs. J. Pharm. Biomed. Anal. 47: 478-486
  • Bertog M, Cuffe JE, Pradervand S, Hummler E, Hartner A, Porst M, Hilgers KF, Rossier BC, Korbmacher C (2008) Aldosterone responsiveness of the epithelial sodium channel (ENaC) in colon is increased in a mouse model for Liddle's syndrome. J. Physiol. 586: 459-475
  • Gambhir L, Höller T, Müller M, Schott G, Vogt H, Detlefsen B, Ebert AK, Fisch M, Beaudoin S, Stein R, Boyadjiev SA, Gearhart JP, Rösch W, Utsch B, Boemers TM, Reutter H, Ludwig M (2008) Epidemiological survey of 214 families with bladder exstrophy-epispadias complex. J. Urol. 179: 1539-1543
  • Simm D, Degenhardt K, Gerdemann C, Völkl TM, Rauch A, Dörr HG (2008) Chronological age of patients with Turner syndrome at diagnosis. Klin. Pädiatr. 220: 16-20
  • Thiel CT, Knebel B, Knerr I, Sticht H, Müller-Wieland D, Zenker M, Reis A, Dörr HG, Rauch A (2008) Two novel mutations in the insulin binding subunit of the insulin receptor gene without insulin binding impairment in a patient with Rabson-Mendenhall syndrome. Mol. Genet. Metab. 94: 356-362
  • Schumacher V, Gueler B, Looijenga LH, Becker JU, Amann K, Engers R, Dotsch J, Stoop H, Schulz W, Royer-Pokora B (2008) Characteristics of testicular dysgenesis syndrome and decreased expression of SRY and SOX9 in Frasier syndrome. Mol. Reprod. Dev. 75: 1484-1494
  • Gbadegesin R, Hinkes BG, Hoskins BE, Vlangos CN, Heeringa SF, Liu J, Loirat C, Ozaltin F, Hashmi S, Ulmer F, Cleper R, Ettenger R, Antignac C, Wiggins RC, Zenker M, Hildebrandt F (2008) Mutations in PLCE1 are a major cause of isolated diffuse mesangial sclerosis (IDMS). Nephrol. Dial. Transplant. 23: 1291-1297
  • Heeringa SF, Vlangos CN, Chernin G, Hinkes B, Gbadegesin R, Liu J, Hoskins BE, Ozaltin F, Hildebrandt F, Members of the APN Study Group (2008) Thirteen novel NPHS1 mutations in a large cohort of children with congenital nephrotic syndrome. Nephrol. Dial. Transplant. 23: 3527-3533
  • Klanke B, Cordasic N, Hartner A, Schmieder RE, Veelken R, Hilgers KF (2008) Blood pressure versus direct mineralocorticoid effects on kidney inflammation and fibrosis in DOCA-salt hypertension. Nephrol. Dial. Transplant. 23: 3456-3463
  • Rüth EM, Dittrich K, Jüngert J, Uder M, Rascher W, Dötsch J (2008) Successful interventional treatment of arteriovenous fistula after kidney biopsy in pediatric patients--a report of three cases. Nephrol. Dial. Transplant. 23: 3215-3218
  • Zeltner R, Hilgers KF, Schmieder RE, Porst M, Schulze BD, Hartner A (2008) A promoter polymorphism of the alpha 8 integrin gene and the progression of autosomal-dominant polycystic kidney disease. Nephron Clin. Pract. 108: c169-175
  • Schanze A, Reulbach U, Scheuchenzuber M, Groschl M, Kornhuber J, Kraus T (2008) Ghrelin and eating disturbances in psychiatric disorders. Neuropsychobiology 57: 126-130
  • Schubert SW, Abendroth A, Kilian K, Vogler T, Mayr B, Knerr I, Hashemolhosseini S (2008) bZIP-Type transcription factors CREB and OASIS bind and stimulate the promoter of the mammalian transcription factor GCMa/Gcm1 in trophoblast cells. Nucleic Acids Res. 36: 3834-3846
  • Boeuf S, Steck E, Pelttari K, Hennig T, Buneß A, Benz K, Witte D, Sültmann H, Poustka A, Richter W (2008) Subtractive gene expression profiling of articular cartilage and mesenchymal stem cells: serpins as cartilage-relevant differentiation markers. Osteoarthritis Cartilage 16: 48-60
  • Gelse K, Mühle C, Knaup K, Swoboda B, Wiesener M, Hennig F, Olk A, Schneider H (2008) Chondrogenic differentiation of growth factor-stimulated precursor cells in cartilage repair tissue is associated with increased HIF-1alpha activity. Osteoarthritis Cartilage 16: 1457-1465
  • Meißner U, Scharf J, Dötsch J, Schroth M (2008) Very early extubation after open-heart surgery in children does not influence cardiac function. Pediatr. Cardiol. 29: 317-320
  • Dötsch J, Müller-Wiefel DE, Kemper MJ (2008) Rituximab: is replacement of cyclophosphamide and calcineurin inhibitors in steroid-dependent nephrotic syndrome possible? Pediatr. Nephrol. 23: 3-7
  • Mühle C, Klinge J, Khrenov AV, Saenko EL, Schneider H (2008) Spectrum of antigenic FVIII domains recognized by antibodies from hemophiliacs. Hämostaseologie 28: S35-36
  • Plank C, Kalb V, Hinkes B, Hildebrandt F, Gefeller O, Rascher W, Arbeitsgemeinschaft für Pädiatrische Nephrologie (2008) Cyclosporin A is superior to cyclophosphamide in children with steroid-resistant nephrotic syndrome-a randomized controlled multicentre trial by the Arbeitsgemeinschaft für Pädiatrische Nephrologie. Pediatr. Nephrol. 23: 1483-1493
  • Chada M, Nögel S, Schmidt AM, Rückel A, Bosselmann S, Walther J, Papadopoulos T, von der Hardt K, Dötsch J, Rascher W, Kandler MA (2008) Anakinra (IL-1R antagonist) lowers pulmonary artery pressure in a neonatal surfactant depleted piglet model. Pediatr. Pulmonol. 43: 851-857
  • Heberlein A, Bleich S, Bayerlein K, Frieling H, Gröschl M, Kornhuber J, Hillemacher T (2008) NGF plasma levels increase due to alcohol intoxication and decrease during withdrawal. Psychoneuroendocrinology 33: 999-1003
  • Rauch A, Thiel CT, Schindler D, Wick U, Crow YJ, Ekici AB, van Essen AJ, Goecke TO, Al-Gazali L, Chrzanowska KH, Zweier C, Brunner HG, Becker K, Curry CJ, Dallapiccola B, Devriendt K, Dörfler A, Kinning E, Megarbane A, Meinecke P, Semple RK, Spranger S, Toutain A, Trembath RC, Voss E, Wilson L, Hennekam R, de Zegher F, Dörr HG, Reis A (2008) Mutations in the pericentrin (PCNT) gene cause primordial dwarfism. Science 319: 816-819
  • Ullmann C, Beck JD, Holter W, Petsch S, Dunst J, Sauer R, Grabenbauer GG (2008) Long-term results following multidisciplinary treatment of localized Ewing's sarcoma in children and adolescents. Strahlenther. Onkol. 184: 137-144
  • Schiessl C, Gravou C, Zernikow B, Sittl R, Griessinger N (2008) Use of patient-controlled analgesia for pain control in dying children. Support. Care Cancer 16: 531-536
  • Höcker B, Kovarik JM, Daniel V, Opelz G, Fehrenbach H, Holder M, Hoppe B, Hoyer P, Jungraithmayr TC, Köpf-Shakib S, Laube GF, Müller-Wiefel DE, Offner G, Plank C, Schröder M, Weber LT, Zimmerhackl LB, Tönshoff B (2008) Pharmacokinetics and immunodynamics of basiliximab in pediatric renal transplant recipients on mycophenolate mofetil comedication. Transplantation 86: 1234-1240
  • Offner G, Toenshoff B, Höcker B, Krauss M, Bulla M, Cochat P, Fehrenbach H, Fischer W, Foulard M, Hoppe B, Hoyer PF, Jungraithmayr TC, Klaus G, Latta K, Leichter H, Mihatsch MJ, Misselwitz J, Montoya C, Müller-Wiefel DE, Neuhaus TJ, Pape L, Querfeld U, Plank C, Schwarke D, Wygoda S, Zimmerhackl LB (2008) Efficacy and safety of basiliximab in pediatric renal transplant patients receiving cyclosporine, mycophenolate mofetil, and steroids. Transplantation 86: 1241-1248
  • Nüsken KD, Dötsch J, Rauh M, Rascher W, Schneider H (2008) Uteroplacental insufficiency after bilateral uterine artery ligation in the rat: impact on postnatal glucose and lipid metabolism and evidence for metabolic programming of the offspring by sham operation. Endocrinology 149: 1056-1063
  • Müller T, Hess MW, Schiefermeier N, Pfaller K, Ebner HL, Heinz-Erian P, Ponstingl H, Partsch J, Röllinghoff B, Köhler H, Berger T, Lenhartz H, Schlenck B, Houwen RJ, Taylor CJ, Zoller H, Lechner S, Goulet O, Utermann G, Ruemmele FM, Huber LA, Janecke AR (2008) MYO5B mutations cause microvillus inclusion disease and disrupt epithelial cell polarity. Nature Genet. 40: 1163-1165
  • Cisse B, Caton ML, Lehner M, Maeda T, Scheu S, Locksley R, Holmberg D, Zweier C, den Hollander NS, Kant SG, Holter W, Rauch A, Zhuang Y, Reizis B (2008) Transcription factor E2-2 is an essential and specific regulator of plasmacytoid dendritic cell development. Cell 135: 37-48
  • Metzler M, Staege MS, Harder L, Mendelova D, Zuna J, Fronkova E, Meyer C, Flohr T, Bednarova D, Harbott J, Langer T, Gesk S, Trka J, Siebert R, Dingermann T, Marschalek R, Niemeyer C, Rascher W (2008) Inv(11)(q21q23) fuses MLL to the Notch co-activator mastermind-like 2 in secondary T-cell acute lymphoblastic leukemia. Leukemia 22: 1807-1811
  • Knerr I, Dost A, Lepler R, Raile K, Schober E, Rascher W, Holl RW; on behalf of the DPV Scientific Initiative Germany and Austria (2008) Tracking and prediction of arterial blood pressure from childhood to young adulthood in 868 patients with type 1 diabetes: A multi-center, longitudinal survey in Germany and Austria. Diabetes Care 31:726-727

Universitätsklinikum Erlangen
Kinder- und Jugendklinik
Lehrstuhl für Kinderheilkunde
Loschgestraße 15
91054 Erlangen
Telefon: 09131 85-33118
Fax: 09131 85-33113

Prof. Dr. med. Joachim Wölfle
Prof. Dr. med. Holm Schneider
Telefon: 09131 85-33775
Fax: 09131 85-33013