Our research aims at elucidating the consequences of an early impairment of organ development for the pathogenesis of diseases during adolescence and adult life. To this purpose, the sequelae of a congenital reduction of nephron numbers or disruption of renal development for the kidney and the cardiovascular system are being studied. We have been focussing on the pathogenic mechanisms of inflammatory renal disease, hypertension, and heart failure. In further studies we are attempting to clarify which placental alterations may lead to defects in organ systems of the offspring and can expedite the onset of later disease. These studies are being performed in collaboration with the Perinatalzentrum Franken.