Genomic aberrations in childhood malignancies


Head of Department:
Prof. Dr. med. Joachim Wölfle

Genomic aberrations in childhood malignancies


Modern molecular biology has advanced understanding of the impact of both heritable and acquired genetic alterations on the development and progression of pediatric tumors. We have been trying to exploit such new information for diagnostic purposes and novel therapeutic approaches, placing emphasis on acute and chronic childhood leukemia, non-Hodgkin lymphoma, Ewing's sarcoma, and other frequent pediatric malignancies. In addition to acquired mutations in the tumor genome, the impact of hereditary single nucleotide polymorphisms on the development of late adverse effects of current cancer therapy, such as hearing loss or cardiomyopathy, is being investigated. Rare tumor entities have been recorded in the German Pediatric Rare Tumor Registry (STEP), which is located in our hospital, and have been further characterized in scientific projects.



Komponentenanalyse der Genexpressionsprofile von zwei MLL-MAML2-positiven Fällen einer akuten lymphatischen Leukämie (T-ALL) im Vergleich mit verwandten Leukämie-Subgruppen.
Principal investigator

Prof. Dr. T. Langer

(until 06/2013)