Prof. Dr. med. Dr. h. c. Wolfgang Rascher

Publikationen unter Beteiligung der Kinderklinik

  • Detyrosinated tubulin is decreased in fetal vessels of preeclampsia placentas.

    Placenta. 2018;62(): 58-65

    Huebner H, Knoerr B, Betzler A, Hartner A, Kehl S, Baier F, Wachter DL, Strick R, Beckmann MW, Fahlbusch FB, Ruebner M

    INTRODUCTION: Preeclampsia is a hypertensive, gestational disease, which is still the leading cause of pregnancy related morbidity and mortality. The impairment of placental angiogenesis and vascularization is discussed to be of...Pubmed

  • Side effects of radiotherapy in breast cancer patients : The Internet as an information source.

    Strahlenther Onkol. 2018;194(2): 136-142

    Janssen S, Käsmann L, Fahlbusch FB, Rades D, Vordermark D

    AIM: Breast cancer is the most common cancer type among women necessitating adjuvant radiotherapy. As the Internet has become a major source of information for cancer patients, this study aimed to evaluate the quality of websites giving information on side effects...Pubmed

  • CTLA4 induction by Rhinovirus (RV) in pediatric asthma

    Allergy. 2018;73(): 301-302

    Koelle J, Haag P, Vuorinen T, Kiefer A, Zimmermann T, Papadopoulos NG, Finotto S

  • [Flight Routes to Germany of Seriously Ill Children and Adolescents From Former Eastern Bloc Countries for Treatment of Renal Failure].

    Klin Padiatr. 2018;():

    Mammadova D, Marek I, Galiano M, Rascher W

    BACKGROUND: Increased patient mobility and restricted treatment of children with end-stage renal disease forced families from the former Eastern Bloc countries to flee with their children to Germany for adequate medical treatment. METHODS: In a case study, the...Pubmed

  • Expression of the Alpha8 Integrin Chain Facilitates Phagocytosis by Renal Mesangial Cells.

    Cell Physiol Biochem. 2018;45(6): 2161-2173

    Marek I, Becker R, Fahlbusch FB, Menendez-Castro C, Rascher W, Daniel C, Volkert G, Hartner A

    BACKGROUND/AIMS: Healing of mesangioproliferative glomerulonephritis involves degradation of excess extracellular matrix, resolution of hypercellularity by apoptosis and phagocytosis of apoptotic cells. Integrin receptors participate in...Pubmed

  • Effect of maternal smoking on stress physiology in healthy neonates.

    J Perinatol. 2018;38(2): 132-136

    Haslinger C, Bamert H, Rauh M, Burkhardt T, Schäffer L

    OBJECTIVE: To assess the impact of maternal smoking during pregnancy (MSDP) on the neonatal hypothalamic-pituitary-adrenal axis. STUDY DESIGN: In a prospective observational study, salivary cortisol and cortisone levels were measured at the fourth day of life during resting conditions and in response to...Pubmed

  • Pharmacology and pharmacokinetics of imatinib in pediatric patients.

    Expert Rev Clin Pharmacol. 2018;11(3): 219-231

    Suttorp M, Bornhäuser M, Metzler M, Millot F, Schleyer E

    INTRODUCTION: The tyrosine kinase inhibitor (TKI) imatinib was rationally designed to target BCR-ABL1 which is constitutively activated in chronic myeloid leukemia (CML). Following the tremendous success in adults, imatinib also became licensed for treatment of CML in minors. The rarity...Pubmed

  • Sustained Need for High-Dose Zinc Supplementation in Children With Acrodermatitis Enteropathica.

    Clin Pediatr (Phila). 2018;57(1): 99-102

    Hammersen J, Has C, Galiano M, Lindner M, Rossi R, Kohlhase J, Schneider H

  • Diminished protein-bound ω-hydroxylated ceramides in the skin of patients with ichthyosis with 12R-lipoxygenase (LOX) or eLOX-3 deficiency.

    Br J Dermatol. 2017;177(4): e119-e121

    Dick A, Tantcheva-Poór I, Oji V, Giehl KA, Fischer J, Krieg P, Schneider H, Rauh M

  • Searching the web: a survey on the quality of advice on postnatal sequelae of intrauterine growth restriction and the implication of developmental origins of health and disease.

    J Dev Orig Health Dis. 2017;8(5): 604-612

    Perzel S, Huebner H, Rascher W, Menendez-Castro C, Hartner A, Fahlbusch FB

    Intrauterine growth restriction (IUGR) and fetal growth restriction (FGR) are pregnancy complications associated with morbidity in later life. Despite a growing body of...Pubmed

  • Enzymatic lipid oxidation by eosinophils propagates coagulation, hemostasis, and thrombotic disease.

    J Exp Med. 2017;214(7): 2121-2138

    Uderhardt S, Ackermann JA, Fillep T, Hammond VJ, Willeit J, Santer P, Mayr M, Biburger M, Miller M, Zellner KR, Stark K, Zarbock A, Rossaint J, Schubert I, Mielenz D, Dietel B, Raaz-Schrauder D, Ay C, Gremmel T, Thaler J, Heim C, Herrmann M, Collins PW, Schabbauer G, Mackman N, Voehringer D, Nadler JL, Lee JJ, Massberg S, Rauh M, Kiechl S...Pubmed

  • IFN-α/IFN-λ responses to respiratory viruses in paediatric asthma.

    Eur Respir J. 2017;49(3):

    Bergauer A, Sopel N, Kroß B, Vuorinen T, Xepapadaki P, Weiss ST, Blau A, Sharma H, Kraus C, Springel R, Rauh M, Mittler S, Graser A, Zimmermann T, Melichar VO, Kiefer A, Kowalski ML, Sobanska A, Jartti T, Lukkarinen H, Papadopoulos NG, Finotto S

  • Oxygen-sensitive regulation and neuroprotective effects of growth hormone-dependent growth factors during early postnatal development.

    Am J Physiol Regul Integr Comp Physiol. 2017;312(4): R539-R548

    Jung S, Boie G, Doerr HG, Trollmann R

    Perinatal hypoxia severely disrupts metabolic and somatotrophic development, as well as cerebral maturational programs. Hypoxia-inducible transcription factors (HIFs) represent the most important endogenous adaptive mechanisms to...Pubmed

  • Automatic recognition of the XLHED phenotype from facial images.

    Am J Med Genet A. 2017;173(9): 2408-2414

    Hadj-Rabia S, Schneider H, Navarro E, Klein O, Kirby N, Huttner K, Wolf L, Orin M, Wohlfart S, Bodemer C, Grange DK

    X-linked hypohidrotic ectodermal dysplasia (XLHED) is a genetic disorder that affects ectodermal structures and presents with a characteristic facial appearance. The ability of automated facial recognition technology to detect the phenotype...Pubmed

  • The oxido-metabolic driver ATF4 enhances temozolamide chemo-resistance in human gliomas.

    Oncotarget. 2017;8(31): 51164-51176

    Chen D, Rauh M, Buchfelder M, Eyupoglu IY, Savaskan N

    Malignant gliomas are devastating neoplasia with limited curative treatment options. Temozolomide (TMZ, Temcat®, Temodal® or Temodar®) is a first-line treatment for malignant gliomas but the development of drug resistance remains a major concern. Activating transcription factor 4...Pubmed

  • Integrin α8 Is Abundant in Human, Rat, and Mouse Trophoblasts.

    Reprod Sci. 2017;24(10): 1426-1437

    Herdl S, Huebner H, Volkert G, Marek I, Menendez-Castro C, Noegel SC, Ruebner M, Rascher W, Hartner A, Fahlbusch FB

    OBJECTIVE: Integrins exert regulatory functions in placentogenesis. Null mutation of certain integrin α subunits leads to placental defects with subsequent fetal growth restriction or embryonic lethality in mice. So far, the placental role of α8...Pubmed

  • Variable White Matter Atrophy and Intellectual Development in a Family With X-linked Creatine Transporter Deficiency Despite Genotypic Homogeneity.

    Pediatr Neurol. 2017;67(): 45-52

    Heussinger N, Saake M, Mennecke A, Dörr HG, Trollmann R

    The X-linked creatine transporter deficiency (CRTD) caused by an SLC6A8 mutation represents the second most common cause of X-linked intellectual disability. The clinical phenotype ranges from mild to severe intellectual...Pubmed

  • [Establishment of Specialized Pediatric Palliative Home Care in the Medical Valley of the European Metropolitan Area Nuremberg].

    Klin Padiatr. 2017;229(2): 82-87

    Hébert S, Gravou-Apostolatou C, Rascher W

    Background As part of the 2007 health reform in Germany the structure of outpatient palliative care for children and adolescents was adopted for the first time and then implemented in Erlangen-Nuremberg in 2009. Methods The introduction of Pediatric Palliative...Pubmed

  • The CLOSED trial; CLOnidine compared with midazolam for SEDation of paediatric patients in the intensive care unit: study protocol for a multicentre randomised controlled trial.

    BMJ Open. 2017;7(6):

    Neubert A, Baarslag MA, Dijk MV, Rosmalen JV, Standing JF, Sheng Y, Rascher W, Roberts D, Winslade J, Rawcliffe L, Hanning SM, Metsvaht T, Giannuzzi V, Larsson P, Pokorná P, Simonetti A, Tibboel D, CloSed Consortium null

    INTRODUCTION: Sedation is an essential...Pubmed

  • Ectodysplasin A in Biological Fluids and Diagnosis of Ectodermal Dysplasia.

    J Dent Res. 2017;96(2): 217-224

    Podzus J, Kowalczyk-Quintas C, Schuepbach-Mallepell S, Willen L, Staehlin G, Vigolo M, Tardivel A, Headon D, Kirby N, Mikkola ML, Schneider H, Schneider P

    The tumor necrosis factor (TNF) family ligand ectodysplasin A (EDA) is produced as 2 full-length splice variants, EDA1 and EDA2, that bind to EDA receptor (EDAR) and X-linked EDA receptor (XEDAR/EDA2R...Pubmed

  • Nrf2-Keap1 pathway promotes cell proliferation and diminishes ferroptosis.

    Oncogenesis. 2017;6(8):

    Fan Z, Wirth AK, Chen D, Wruck CJ, Rauh M, Buchfelder M, Savaskan N

    Cancer cells are hallmarked by high proliferation and imbalanced redox consumption and signaling. Various oncogenic pathways such as proliferation and evading cell death converge on redox-dependent signaling processes. Nrf2 is a key regulator in these redox-dependent events and operates in...Pubmed

  • The Phenotypic Spectrum of Nephropathies Associated with Mutations in Diacylglycerol Kinase ?.

    J Am Soc Nephrol. 2017;28(10): 3066-3075

    Azukaitis K, Simkova E, Majid MA, Galiano M, Benz K, Amann K, Bockmeyer C, Gajjar R, Meyers KE, Cheong HI, Lange-Sperandio B, Jungraithmayr T, Frémeaux-Bacchi V, Bergmann C, Bereczki C, Miklaszewska M, Csuka D, Prohászka Z, Gipson P, Sampson MG, Lemaire M, Schaefer F

    The recent discovery of mutations in the gene encoding...Pubmed

  • Neurodevelopmental outcomes of extremely low birthweight infants randomised to different PCO2 targets: the PHELBI follow-up study.

    Arch Dis Child Fetal Neonatal Ed. 2017;102(5): F376-F382

    Thome UH, Genzel-Boroviczeny O, Bohnhorst B, Schmid M, Fuchs H, Rohde O, Avenarius S, Topf HG, Zimmermann A, Faas D, Timme K, Kleinlein B, Buxmann H, Schenk W, Segerer H, Teig N, Bläser A, Hentschel R, Heckmann M, Schlösser R, Peters J, Rossi R, Rascher W, Böttger R, Seidenberg J...Pubmed

  • Microbubbles in macrocysts - Contrast-enhanced ultrasound assisted sclerosant therapy of a congenital macrocystic lymphangioma: a case report.

    BMC Med Imaging. 2017;17(1):

    Menendez-Castro C, Zapke M, Fahlbusch F, von Goessel H, Rascher W, Jüngert J

    BACKGROUND: Congenital cystic lymphangiomas are benign malformations due to a developmental disorder of lymphatic vessels. Besides surgical excision, sclerosant therapy of these lesions by intracavitary injection of...Pubmed

  • Safety profiles of iron chelators in young patients with haemoglobinopathies.

    Eur J Haematol. 2017;98(3): 198-217

    Botzenhardt S, Li N, Chan EW, Sing CW, Wong IC, Neubert A

    BACKGROUND: This review describes the safety of deferoxamine (DFO), deferiprone (DFP), deferasirox (DFX) and combined therapy in young patients less than 25 yr of age with haemoglobinopathies. METHODS: Searches in electronic literature databases were performed. Studies reporting adverse...Pubmed

  • Multispectral Optoacoustic Tomography for Assessment of Crohn's Disease Activity.

    N Engl J Med. 2017;376(13): 1292-1294

    Knieling F, Neufert C, Hartmann A, Claussen J, Urich A, Egger C, Vetter M, Fischer S, Pfeifer L, Hagel A, Kielisch C, Görtz RS, Wildner D, Engel M, Röther J, Uter W, Siebler J, Atreya R, Rascher W, Strobel D, Neurath MF, Waldner MJ

  • Virtual reality jogging as a novel exposure paradigm for the acute urge to be physically active in patients with eating disorders: Implications for treatment.

    Int J Eat Disord. 2017;50(11): 1243-1246

    Paslakis G, Fauck V, Röder K, Rauh E, Rauh M, Erim Y

    The acute urge to be physically active is a relevant clinical phenomenon in patients suffering from eating disorders. In this study with n = 20 female patients with anorexia nervosa and n = 10 female patients...Pubmed

  • Intermediate Follow-up of Pediatric Patients With Hemolytic Uremic Syndrome During the 2011 Outbreak Caused by E. coli O104:H4.

    Clin Infect Dis. 2017;64(12): 1637-1643

    Loos S, Aulbert W, Hoppe B, Ahlenstiel-Grunow T, Kranz B, Wahl C, Staude H, Humberg A, Benz K, Krause M, Pohl M, Liebau MC, Schild R, Lemke J, Beringer O, Müller D, Härtel C, Wigger M, Vester U, Konrad M, Haffner D, Pape L, Oh J, Kemper MJ

    Background.: In 2011 Escherichia coli O104:H4 caused an...Pubmed

  • Expression and Regulation of Retinoic Acid Receptor Responders in the Human Placenta.

    Reprod Sci. 2017;():

    Huebner H, Hartner A, Rascher W, Strick R R, Kehl S, Heindl F, Wachter DL, Beckmann MW, Fahlbusch FB, Ruebner M

    INTRODUCTION: Retinoic acid (RA) signaling through its receptors (RARA, RARB, RARG, and the retinoic X receptor RXRA) is essential for healthy placental and fetal development. An important group of genes regulated by RA are the RA receptor...Pubmed

  • SIRT1 regulates Mxd1 during malignant melanoma progression.

    Oncotarget. 2017;8(70): 114540-114553

    Meliso FM, Micali D, Silva CT, Sabedot TS, Coetzee SG, Koch A, Fahlbusch FB, Noushmehr H, Schneider-Stock R, Jasiulionis MG

    In a murine melanoma model, malignant transformation promoted by a sustained stress condition was causally related to increased levels of reactive oxygen species resulting in DNA damage and massive epigenetic alterations. Since the chromatin...Pubmed

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