Prof. Dr. med. Dr. h. c. Wolfgang Rascher

Publikationen unter Beteiligung der Kinderklinik

  • Intrauterine growth restriction - impact on cardiovascular diseases later in life.

    Mol Cell Pediatr. 2018;5(1):

    Menendez-Castro C, Rascher W, Hartner A

    Intrauterine growth restriction (IUGR) is a fetal pathology which leads to increased risk for certain neonatal complications. Furthermore, clinical and experimental studies revealed that IUGR is associated with a significantly higher incidence of metabolic, renal and cardiovascular diseases (CVD) later in...Pubmed

  • Prospective, randomized, double-blind, placebo-controlled phase IIa clinical trial on the effects of an estrogen-progestin combination as add-on to inpatient psychotherapy in adult female patients suffering from anorexia nervosa.

    BMC Psychiatry. 2018;18(1):

    Paslakis G, Maas S, Gebhardt B, Mayr A, Rauh M, Erim Y

    BACKGROUND: There is a need for novel treatment approaches in anorexia nervosa (AN). While there is broad knowledge with regard to altered appetite...Pubmed

  • Attenuation of Mammary Gland Dysplasia and Feeding Difficulties in Tabby Mice by Fetal Therapy.

    J Mammary Gland Biol Neoplasia. 2018;23(3): 125-138

    Wahlbuhl M, Schuepbach-Mallepell S, Kowalczyk-Quintas C, Dick A, Fahlbusch FB, Schneider P, Schneider H

    Hypohidrotic ectodermal dysplasias (HED) are hereditary differentiation disorders of multiple ectodermal structures including the mammary gland. The X-linked form of HED (XLHED) is caused by a lack of the secreted...Pubmed

  • Detyrosinated tubulin is decreased in fetal vessels of preeclampsia placentas.

    Placenta. 2018;62(): 58-65

    Huebner H, Knoerr B, Betzler A, Hartner A, Kehl S, Baier F, Wachter DL, Strick R, Beckmann MW, Fahlbusch FB, Ruebner M

    INTRODUCTION: Preeclampsia is a hypertensive, gestational disease, which is still the leading cause of pregnancy related morbidity and mortality. The impairment of placental angiogenesis and vascularization is discussed to be of...Pubmed

  • The research gap in chronic paediatric pain: A systematic review of randomised controlled trials.

    Eur J Pain. 2018;22(2): 261-271

    Boulkedid R, Abdou AY, Desselas E, Monégat M, de Leeuw TG, Avez-Couturier J, Dugue S, Mareau C, Charron B, Alberti C, Kaguelidou F, GAPP Consortium null, Bali D, Hoxha Qosja A, Kola E, Talvik I, Andrieu-Galien J, Annequin D, Blanchet R, Desguerre I, Fournier-Charrière E, Tourniaire B, Wood C, Neubert A, Trollmann R, Wimmer S, Garini E, Mammi P...Pubmed

  • Inhibiting Interleukin 36 Receptor Signaling Reduces Fibrosis in Mice with Chronic Intestinal Inflammation.

    Gastroenterology. 2018;():

    Scheibe K, Kersten C, Schmied A, Vieth M, Primbs T, Carlé B, Knieling F, Claussen J, Klimowicz AC, Zheng J, Baum P, Meyer S, Schürmann S, Friedrich O, Waldner MJ, Rath T, Wirtz S, Kollias G, Ekici AB, Atreya R, Raymond EL, Mbow ML, Neurath MF, Neufert C

    BACKGROUND & AIMS: Intestinal fibrosis is a long-term complication...Pubmed

  • Sweating ability of patients with p63-associated syndromes.

    Eur J Pediatr. 2018;177(11): 1727-1731

    Ferstl P, Wohlfart S, Schneider H

    Sweating deficiency has been reported to represent a cardinal symptom of ectrodactyly-ectodermal dysplasia-cleft lip/palate syndrome and ankyloblepharon-ectodermal dysplasia-cleft lip/palate syndrome, two rare p63-associated disorders. According to online resources, hypohidrosis may lead to most life-threatening complications in...Pubmed

  • Soluble ST2 regulation by rhinovirus and 25(OH)-vitamin D3 in the blood of asthmatic children.

    Clin Exp Immunol. 2018;193(2): 207-220

    Haag P, Sharma H, Rauh M, Zimmermann T, Vuorinen T, Papadopoulos NG, Weiss ST, Finotto S

    Paediatric asthma exacerbations are often caused by rhinovirus (RV). Moreover, 25(OH)-vitamin D3 (VitD3) deficiency during infancy was found associated with asthma. Here, we investigated the innate immune responses to RV and their possible...Pubmed

  • Long-Term Effects of Inhaled Budesonide for Bronchopulmonary Dysplasia.

    N Engl J Med. 2018;378(2): 148-157

    Bassler D, Shinwell ES, Hallman M, Jarreau PH, Plavka R, Carnielli V, Meisner C, Engel C, Koch A, Kreutzer K, van den Anker JN, Schwab M, Halliday HL, Poets CF, Neonatal European Study of Inhaled Steroids Trial Group null, Zlatohlávková B, Marková D, Fleischnerová A, Seipolt B, Walter B, Lopez E, Massie-Vuillemin L, Delort-Germes E, Cautru F, Richardson J, Dadoun...Pubmed

  • Side effects of radiotherapy in breast cancer patients : The Internet as an information source.

    Strahlenther Onkol. 2018;194(2): 136-142

    Janssen S, Käsmann L, Fahlbusch FB, Rades D, Vordermark D

    AIM: Breast cancer is the most common cancer type among women necessitating adjuvant radiotherapy. As the Internet has become a major source of information for cancer patients, this study aimed to evaluate the quality of websites giving information on side effects...Pubmed

  • Raster-Scanning Optoacoustic Mesoscopy for Gastrointestinal Imaging at High Resolution.

    Gastroenterology. 2018;154(4): 807-809.e3

    Knieling F, Gonzales Menezes J, Claussen J, Schwarz M, Neufert C, Fahlbusch FB, Rath T, Thoma OM, Kramer V, Menchicchi B, Kersten C, Scheibe K, Schürmann S, Carlé B, Rascher W, Neurath MF, Ntziachristos V, Waldner MJ

  • Adrenal crisis in a 14-year-old boy 12 years after hematopoietic stem cell transplantation.

    Endocrinol Diabetes Metab Case Rep. 2018;2018():

    Penger T, Albrecht A, Marx M, Stachel D, Metzler M, Dörr HG

    We report on a boy of Albanian descent with the history of juvenile myelomonocytic leukemia (JMML). JMML was diagnosed at the age of 17 months and treated by hematopoietic stem cell transplantation (HSCT). At the age of 14.3 years, about 12 years after HSCT, he...Pubmed

  • Complex lipid globules in early-life nutrition improve long-term metabolic phenotype in intra-uterine growth-restricted rats.

    Br J Nutr. 2018;120(7): 763-776

    Teller IC, Hoyer-Kuhn H, Brönneke H, Nosthoff-Horstmann P, Oosting A, Lippach G, Wohlfarth M, Rauh M, van der Beek EM, Dötsch J, Nüsken KD

    Intra-uterine growth restriction (IUGR) is associated with adverse metabolic outcome later in life. Healthy mice challenged with a Western-style diet (WSD...Pubmed

  • Successful eradication of newly acquired MRSA in six of seven patients with cystic fibrosis applying a short-term local and systemic antibiotic scheme.

    BMC Pulm Med. 2018;18(1):

    Kiefer A, Bogdan C, Melichar VO

    BACKGROUND: In individuals with cystic fibrosis (CF), colonization with methicillin-resistant Staphylococcus aureus (MRSA) was reported to be associated with a deterioration of pulmonary disease as reflected by an accelerated decline in lung function...Pubmed

  • TSC-associated neuropsychiatric disorders (TAND): findings from the TOSCA natural history study.

    Orphanet J Rare Dis. 2018;13(1):

    de Vries PJ, Belousova E, Benedik MP, Carter T, Cottin V, Curatolo P, Dahlin M, D'Amato L, d'Augères GB, Ferreira JC, Feucht M, Fladrowski C, Hertzberg C, Jozwiak S, Kingswood JC, Lawson JA, Macaya A, Marques R, Nabbout R, O'Callaghan F, Qin J, Sander V, Sauter M, Shah S, Takahashi Y, Touraine R, Youroukos S, Zonnenberg B, Jansen AC, TOSCA...Pubmed

  • Birth Sizes of Neonates with Congenital Adrenal Hyperplasia Secondary to 21-Hydroxylase Deficiency.

    J Clin Res Pediatr Endocrinol. 2018;():

    Dörr HG, Penger T, Albrecht A, Marx M, Völkl TMK

    OBJECTIVE: Classic congenital adrenal hyperplasia secondary to 21-hydroxylase deficiency (CAH) is characterized by increased prenatal adrenal androgen secretion. There are few reports in the literature showing higher birth weight and length in CAH newborns. METHODS: We...Pubmed

  • Neonatal nephron loss during active nephrogenesis - detrimental impact with long-term renal consequences.

    Sci Rep. 2018;8(1):

    Menendez-Castro C, Nitz D, Cordasic N, Jordan J, Bäuerle T, Fahlbusch FB, Rascher W, Hilgers KF, Hartner A

    Neonatal nephron loss may follow hypoxic-ischemic events or nephrotoxic medications. Its long-term effects on the kidney are still unclear. Unlike term infants, preterm neonates less than 36 weeks gestational age show ongoing...Pubmed

  • Characterization and diagnostic application of genomic NPM-ALK fusion sequences in anaplastic large-cell lymphoma.

    Oncotarget. 2018;9(41): 26543-26555

    Krumbholz M, Woessmann W, Zierk J, Seniuk D, Ceppi P, Zimmermann M, Singh VK, Metzler M, Damm-Welk C

    Nucleophosmin-anaplastic lymphoma kinase (NPM-ALK) fusion genes resulting from the translocation t(2;5)(p23;q35) are present in almost 90% of childhood ALK-positive anaplastic large-cell lymphomas (ALCL...Pubmed

  • MECOM-associated syndrome: a heterogeneous inherited bone marrow failure syndrome with amegakaryocytic thrombocytopenia.

    Blood Adv. 2018;2(6): 586-596

    Germeshausen M, Ancliff P, Estrada J, Metzler M, Ponstingl E, Rütschle H, Schwabe D, Scott RH, Unal S, Wawer A, Zeller B, Ballmaier M

    Heterozygous mutations in MECOM (MDS1 and EVI1 complex locus) have been reported to be causative of a rare association of congenital amegakaryocytic thrombocytopenia and...Pubmed

  • Trial of Fingolimod versus Interferon Beta-1a in Pediatric Multiple Sclerosis.

    N Engl J Med. 2018;379(11): 1017-1027

    Chitnis T, Arnold DL, Banwell B, Brück W, Ghezzi A, Giovannoni G, Greenberg B, Krupp L, Rostasy K, Tardieu M, Waubant E, Wolinsky JS, Bar-Or A, Stites T, Chen Y, Putzki N, Merschhemke M, Gärtner J, PARADIGMS Study Group null, Kornberg A, Bajer-Kornek B, Likhachev S, Pereira Gomes Neto A, Diniz D, Paz J, Alvarenga R, Bojinova-Tchamova V, Mah J, Venkateswaran...Pubmed

  • Miscarriages in families with an offspring that have classic congenital adrenal hyperplasia and 21-hydroxylase deficiency.

    BMC Pregnancy Childbirth. 2018;18(1):

    Dörr HG, Hess J, Penger T, Marx M, Oppelt P

    BACKGROUND: The most common form of congenital adrenal hyperplasia is 21-hydroxylase deficiency (CAH). Both men and women with classic CAH have lower fertility rates than the general population, and an increased rate of miscarriages has been reported in...Pubmed

  • Isolation of a unique hepatic stellate cell population expressing integrin α8 from embryonic mouse livers.

    Dev Dyn. 2018;247(6): 867-881

    Ogawa T, Li Y, Lua I, Hartner A, Asahina K

    BACKGROUND: Hepatic stellate cells (HSCs) play an important role in liver fibrogenesis. However, little is known about their phenotype and role in liver development. The aim of this study is to identify specific markers for embryonic HSCs. RESULTS: Using antibodies against ALCAM...Pubmed

  • Expression and Regulation of Retinoic Acid Receptor Responders in the Human Placenta.

    Reprod Sci. 2018;25(9): 1357-1370

    Huebner H, Hartner A, Rascher W, Strick R R, Kehl S, Heindl F, Wachter DL, Beckmann MW, Fahlbusch FB, Ruebner M

    INTRODUCTION: Retinoic acid (RA) signaling through its receptors (RARA, RARB, RARG, and the retinoic X receptor RXRA) is essential for healthy placental and fetal development. An important group of genes regulated by RA are the RA...Pubmed

  • Local recurrence of breast cancer: conventionally fractionated partial external beam re-irradiation with curative intention.

    Strahlenther Onkol. 2018;194(9): 806-814

    Janssen S, Rades D, Meyer A, Fahlbusch FB, Wildfang I, Meier A, Schild S, Christiansen H, Henkenberens C

    PURPOSE: To assess the outcome of breast cancer patients with local recurrence who underwent partial external beam re-irradiation (re-RT) either as part of a second breast-conserving therapy or...Pubmed

  • Multidisciplinary Late Effects Clinics for Childhood Cancer Survivors in Germany - a Two-Center Study.

    Oncology Research and Treatment. 2018;41(7-8):

    Gebauer J, Rieken S, Schuster S, Hahn B, Gebauer N, Meidenbauer N, Brabant G, Metzler M, Langer T

  • Benign epilepsy with centrotemporal spikes: Correlating spike frequency and neuropsychology.

    Acta Neurol Scand. 2018;138(6): 475-481

    Tacke M, Rupp N, Gerstl L, Heinen F, Vill K, Bonfert M, Neubauer BA, Bast T, Borggraefe I, Further Members of the German HEAD Study Group null, Baumeister FAM, Baethmann M, Schreiber-Gollwitzer B, Bentele K, Blank C, Held J, Blank HM, Liebrich K, Bode H, Braun J, Bosch F, Wagner R, Brandl U, Wetzel K, Brockmann K, Schlockwerder C, Dahlem P...Pubmed

  • Short-term adverse effects of testosterone used for priming in prepubertal boys before growth hormone stimulation test.

    J Pediatr Endocrinol Metab. 2018;31(1): 21-24

    Albrecht A, Penger T, Marx M, Hirsch K, Dörr HG

    BACKGROUND: Despite the fact that priming with sex steroids in prepubertal children before growth hormone (GH) provocative tests is recommended, there is an ongoing controversial discussion about the appropriate age of the children, the drug used for...Pubmed

  • A Comparison of GFR Estimation Formulae in Pediatric Oncology.

    Klin Padiatr. 2018;230(3): 142-150

    Rechenauer T, Zierk J, Gräfe D, Rascher W, Rauh M, Metzler M

    BACKGROUND: Application of potentially nephrotoxic chemotherapy requires continuous monitoring of renal function for toxicity and dosing. Novel pediatric glomerular filtration rate (GFR) estimating equations including cystatin C have been proposed to enhance the reliability of GFR...Pubmed

  • [Medication safety in children : What role do dosing and formulations play?]

    Bundesgesundheitsblatt Gesundheitsforschung, Gesundheitsschutz. 2018;61(9): 1139-1145

    Neubert A, Rascher W

    Medication errors are more common in children compared to adults due to often missing efficacy evidence and limited or missing regulatory approvals for paediatric drugs.Roots of errors are located at different levels. They result, for example, from missing clinical studies that...Pubmed

  • Genome-wide association study identifies multiple new loci associated with Ewing sarcoma susceptibility.

    Nat Commun. 2018;9(1):

    Machiela MJ, Grünewald TGP, Surdez D, Reynaud S, Mirabeau O, Karlins E, Rubio RA, Zaidi S, Grossetete-Lalami S, Ballet S, Lapouble E, Laurence V, Michon J, Pierron G, Kovar H, Gaspar N, Kontny U, González-Neira A, Picci P, Alonso J, Patino-Garcia A, Corradini N, Bérard PM, Freedman ND, Rothman N, Dagnall CL, Burdett L, Jones K, Manning M...Pubmed

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