Prof. Dr. med. Dr. h. c. Wolfgang Rascher

Publikationen unter Beteiligung der Kinderklinik

  • [Flight Routes to Germany of Seriously Ill Children and Adolescents From Former Eastern Bloc Countries for Treatment of Renal Failure].

    Klin Padiatr. 2018;():

    Mammadova D, Marek I, Galiano M, Rascher W

    BACKGROUND: Increased patient mobility and restricted treatment of children with end-stage renal disease forced families from the former Eastern Bloc countries to flee with their children to Germany for adequate medical treatment. METHODS: In a case study, the...Pubmed

  • Expression of the Alpha8 Integrin Chain Facilitates Phagocytosis by Renal Mesangial Cells.

    Cell Physiol Biochem. 2018;45(6): 2161-2173

    Marek I, Becker R, Fahlbusch FB, Menendez-Castro C, Rascher W, Daniel C, Volkert G, Hartner A

    BACKGROUND/AIMS: Healing of mesangioproliferative glomerulonephritis involves degradation of excess extracellular matrix, resolution of hypercellularity by apoptosis and phagocytosis of apoptotic cells. Integrin receptors participate in...Pubmed

  • Effect of maternal smoking on stress physiology in healthy neonates.

    J Perinatol. 2018;38(2): 132-136

    Haslinger C, Bamert H, Rauh M, Burkhardt T, Schäffer L

    OBJECTIVE: To assess the impact of maternal smoking during pregnancy (MSDP) on the neonatal hypothalamic-pituitary-adrenal axis. STUDY DESIGN: In a prospective observational study, salivary cortisol and cortisone levels were measured at the fourth day of life during resting conditions and in response to...Pubmed

  • Pharmacology and pharmacokinetics of imatinib in pediatric patients.

    Expert Rev Clin Pharmacol. 2018;11(3): 219-231

    Suttorp M, Bornhäuser M, Metzler M, Millot F, Schleyer E

    INTRODUCTION: The tyrosine kinase inhibitor (TKI) imatinib was rationally designed to target BCR-ABL1 which is constitutively activated in chronic myeloid leukemia (CML). Following the tremendous success in adults, imatinib also became licensed for treatment of CML in minors. The rarity...Pubmed

  • Sustained Need for High-Dose Zinc Supplementation in Children With Acrodermatitis Enteropathica.

    Clin Pediatr (Phila). 2018;57(1): 99-102

    Hammersen J, Has C, Galiano M, Lindner M, Rossi R, Kohlhase J, Schneider H

  • Detyrosinated tubulin is decreased in fetal vessels of preeclampsia placentas.

    Placenta. 2018;62(): 58-65

    Huebner H, Knoerr B, Betzler A, Hartner A, Kehl S, Baier F, Wachter DL, Strick R, Beckmann MW, Fahlbusch FB, Ruebner M

    INTRODUCTION: Preeclampsia is a hypertensive, gestational disease, which is still the leading cause of pregnancy related morbidity and mortality. The impairment of placental angiogenesis and vascularization is discussed to be of...Pubmed

  • Side effects of radiotherapy in breast cancer patients : The Internet as an information source.

    Strahlenther Onkol. 2018;194(2): 136-142

    Janssen S, Käsmann L, Fahlbusch FB, Rades D, Vordermark D

    AIM: Breast cancer is the most common cancer type among women necessitating adjuvant radiotherapy. As the Internet has become a major source of information for cancer patients, this study aimed to evaluate the quality of websites giving information on side effects...Pubmed

  • Comparable Cerebral Blood Flow in Both Hemispheres During Regional Cerebral Perfusion in Infant Aortic Arch Surgery.

    Ann Thorac Surg. 2017;103(1): 178-185

    Rüffer A, Tischer P, Münch F, Purbojo A, Toka O, Rascher W, Cesnjevar RA, Jüngert J

    Cerebral protection during aortic arch repair can be provided by regional cerebral perfusion (RCP) through the innominate artery. This study addresses the question of an adequate bilateral blood flow in both hemispheres...Pubmed

  • Hypoxia inducible factor stabilization improves defective ischemia-induced angiogenesis in a rodent model of chronic kidney disease.

    Kidney Int. 2017;91(3): 616-627

    Schellinger IN, Cordasic N, Panesar J, Buchholz B, Jacobi J, Hartner A, Klanke B, Jakubiczka-Smorag J, Burzlaff N, Heinze E, Warnecke C, Raaz U, Willam C, Tsao PS, Eckardt KU, Amann K, Hilgers KF

    Chronic kidney disease (CKD) is associated with increased risk and worse prognosis of cardiovascular...Pubmed

  • [Bilateral posterior persistent hyperplastic primary vitreous].

    Ophthalmologe. 2017;():

    Hohberger B, Knorr HLJ, Mardin CY, Trollmann R, von Marchtaler P, Gusek-Schneider GC

    Bilateral persistent hyperplastic primary vitreous (PHPV) represents a rare entity of a congential malformation. This casuistic presents for the first time in the German literature the case of a 4-month-old child with bilateral posterior PHPV.

  • Intrauterine Growth Restriction (IUGR) Induces Signs of Subclinical Atherosclerosis in 6-Year-Old Infants Despite Absence Of Excessive Growth.

    Klin Padiatr. 2017;229(4): 209-215

    Tzschoppe A, von Kries R, Struwe E, Rascher W, Dörr HG, Jüngert J, Rauh M, Beckmann M, Schild R, Goecke TW, Dötsch J

    Background Postnatal catch-up growth and rapid weight gain after intrauterine growth restriction (IUGR) seem to increase the risk for later disease. This study aimed...Pubmed

  • Increased salt consumption induces body water conservation and decreases fluid intake.

    J Clin Invest. 2017;127(5): 1932-1943

    Rakova N, Kitada K, Lerchl K, Dahlmann A, Birukov A, Daub S, Kopp C, Pedchenko T, Zhang Y, Beck L, Johannes B, Marton A, Müller DN, Rauh M, Luft FC, Titze J

    BACKGROUND: The idea that increasing salt intake increases drinking and urine volume is widely accepted. We tested the hypothesis that an increase in salt intake of 6 g/d would...Pubmed

  • Childhood cancer predisposition syndromes-A concise review and recommendations by the Cancer Predisposition Working Group of the Society for Pediatric Oncology and Hematology.

    Am J Med Genet A. 2017;173(4): 1017-1037

    Ripperger T, Bielack SS, Borkhardt A, Brecht IB, Burkhardt B, Calaminus G, Debatin KM, Deubzer H, Dirksen U, Eckert C, Eggert A, Erlacher M, Fleischhack G, Frühwald MC, Gnekow A, Goehring G, Graf N, Hanenberg H, Hauer J, Hero B, Hettmer S, von Hoff K...Pubmed

  • Sex differences in the development of vascular and renal lesions in mice with a simultaneous deficiency of Apoe and the integrin chain Itga8.

    Biol Sex Differ. 2017;8(): 19

    Marek I, Canu M, Cordasic N, Rauh M, Volkert G, Fahlbusch FB, Rascher W, Hilgers KF, Hartner A, Menendez-Castro C

    Apoe-deficient (Apoe(-/-)) mice develop progressive atherosclerotic lesions with age but no severe renal pathology in the absence of additional challenges. We recently described...Pubmed

  • [Partial homonymous hemianopia of traumatic origin after riding a high-speed amusement ride].

    Ophthalmologe. 2017;114(8): 741-744

    Hohberger B, Trollmann R, Rompel O, Gölitz P, Gusek-Schneider GC

    Amusement park injuries have become more common in recent years. Especially neurological symptoms dominate clinical findings. In this article, the case of a 15-year-old child with homonymous hemianopia due to an atypical intracranial bleeding with subdural hematoma...Pubmed

  • Inosine Released from Dying or Dead Cells Stimulates Cell Proliferation via Adenosine Receptors.

    Front Immunol. 2017;8(): 504

    Chen J, Chaurio RA, Maueröder C, Derer A, Rauh M, Kost A, Liu Y, Mo X, Hueber A, Bilyy R, Herrmann M, Zhao Y, Munoz LE

    Many antitumor therapies induce apoptotic cell death in order to cause tumor regression. Paradoxically, apoptotic cells are also known to promote wound healing, cell proliferation, and tumor cell repopulation in...Pubmed

  • Systematic comparison of donor chimerism in peripheral blood and bone marrow after hematopoietic stem cell transplantation.

    Blood Cancer J. 2017;7(6): e566

    Bach C, Steffen M, Roesler W, Winkler J, Mackensen A, Stachel KD, Metzler M, Spriewald BM

  • Hypermethylation and loss of retinoic acid receptor responder 1 expression in human choriocarcinoma.

    J Exp Clin Cancer Res. 2017;36(1):

    Huebner H, Strick R, Wachter DL, Kehl S, Strissel PL, Schneider-Stock R, Hartner A, Rascher W, Horn LC, Beckmann MW, Ruebner M, Fahlbusch FB

    BACKGROUND: Human placental development resembles tumorigenesis, due to the invasive and fusogenic potential of trophoblasts. However, these features are tightly controlled in...Pubmed

  • Recent Progress of the ARegPKD Registry Study on Autosomal Recessive Polycystic Kidney Disease.

    Front Pediatr. 2017;5():

    Ebner K, Schaefer F, Liebau MC, ARegPKD Consortium null, Eid LA, Ranguelov N, Adams B, van Hoeck K, Raes A, Mekahli D, Collard L, Lombet J, Maquet J, Cachat F, Schalk G, Seeman T, Ortiz Bruechle N, Zerres K, Thumfart J, Briese S, Querfeld U, Hoppe B, Feldkoetter M, Kirschstein M, Gruening G, Beck BB, Benzing T, Buettner R, Dötsch J, Goebel H, Grundmann...Pubmed

  • Rhinovirus species/genotypes and interferon-?: subtypes, receptor and polymorphisms - missing pieces of the puzzle of childhood asthma?

    Eur Respir J. 2017;49(3):

    Bergauer A, Sopel N, Kroß B, Vuorinen T, Xepapadaki P, Weiss ST, Blau A, Sharma H, Kraus C, Springel R, Rauh M, Mittler S, Graser A, Zimmermann T, Melichar VO, Kiefer A, Kowalski ML, Sobanska A, Jartti T, Lukkarinen H, Papadopoulos NG, Finotto S

  • Recurrent Somatic PDGFRB Mutations in Sporadic Infantile/Solitary Adult Myofibromas But Not in Angioleiomyomas and Myopericytomas.

    Am J Surg Pathol. 2017;41(2): 195-203

    Agaimy A, Bieg M, Michal M, Geddert H, Märkl B, Seitz J, Moskalev EA, Schlesner M, Metzler M, Hartmann A, Wiemann S, Michal M, Mentzel T, Haller F

    Infantile myofibroma (MF) is an uncommon benign myofibroblastic tumor of infancy and childhood. Solitary adult MF shares similar features with...Pubmed

  • Adhesive blood microsampling systems for steroid measurement via LC-MS/MS in the rat.

    Steroids. 2017;120(): 1-6

    Heussner K, Rauh M, Cordasic N, Menendez-Castro C, Huebner H, Ruebner M, Schmidt M, Hartner A, Rascher W, Fahlbusch FB

    INTRODUCTION: Liquid Chromatography Tandem Mass Spectrometry (LC-MS/MS) allows for the direct analysis of multiple hormones in a single probe with minimal sample volume. Rodent-based animal studies strongly rely on microsampling, such...Pubmed

  • Chemotherapeutic xCT inhibitors sorafenib and erastin unraveled with the synaptic optogenetic function analysis tool.

    Cell Death Discov. 2017;3():

    Dahlmanns M, Yakubov E, Chen D, Sehm T, Rauh M, Savaskan N, Wrosch JK

    In the search for new potential chemotherapeutics, the compounds' toxicity to healthy cells is an important factor. The brain with its functional units, the neurons, is especially endangered during the radio- and chemotherapeutic treatment of brain...Pubmed

  • A multidisciplinary systematic review of the treatment for chronic idiopathic tinnitus.

    Eur Arch Otorhinolaryngol. 2017;274(5): 2079-2091

    Zenner HP, Delb W, Kröner-Herwig B, Jäger B, Peroz I, Hesse G, Mazurek B, Goebel G, Gerloff C, Trollmann R, Biesinger E, Seidler H, Langguth B

    The majority of tinnitus patients are affected by chronic idiopathic tinnitus, and almost 60 different treatment modalities have been reported. The present study is a...Pubmed

  • Assignment of weight-based antibody units for four additional serotypes to a human anti-pneumococcal standard reference serum 007sp.

    Clin Vaccine Immunol. 2017;24(9):

    Goldblatt D, McKeen A, Burbidge P, McElhiney S, McLaughlin L, Johnson A, Rauh M, Giardina PC

    The pneumococcal ELISA reference standard serum, Lot 89SF, has been in use since 1990 and was replaced with a new reference standard serum, 007sp in 2013. This serum was generated under an FDA-approved...Pubmed

  • Hypohidrotic Ectodermal Dysplasia: Breastfeeding Complications Due to Impaired Breast Development.

    Geburtsh Frauenheilk. 2017;77(4): 377-382

    Wahlbuhl-Becker M, Faschingbauer F, Beckmann MW, Schneider H

    Background X-linked hypohidrotic ectodermal dysplasia (XLHED), the most common form of ectodermal dysplasia, is caused by mutations in the gene EDA. While only affected men develop the full-blown clinical picture, females who are heterozygous for an EDA...Pubmed

  • Blunted transcriptional response to skeletal muscle ischemia in rats with chronic kidney disease: potential role for impaired ischemia-induced angiogenesis.

    Physiol Genomics. 2017;49(4): 230-237

    Heiss RU, Fahlbusch F, Jacobi J, Daniel C, Ekici AB, Cordasic N, Amann K, Hartner A, Hilgers KF

    Chronic kidney disease (CKD) is associated with increased cardiovascular morbidity and mortality. Previous studies indicated an impairment of ischemia-induced angiogenesis in...Pubmed

  • Salivary Markers for Quantitative Dehydration Estimation During Physical Exercise.

    IEEE J Biomed Health Inform. 2017;21(5): 1306-1314

    Ring M, Lohmueller C, Rauh M, Mester J, Eskofier BM

    Salivary markers have been proposed as noninvasive and easy-to-collect indicators of dehydrations during physical exercise. It has been demonstrated that threshold-based classifications can distinguish dehydrated from euhydrated subjects. However, considerable challenges were...Pubmed

  • Rare Variant of GM2 Gangliosidosis through Activator-Protein Deficiency.

    Neuropediatrics. 2017;48(2): 127-130

    Brackmann F, Kehrer C, Kustermann W, Böhringer J, Krägeloh-Mann I, Trollmann R

    GM2 gangliosidosis, AB variant, is a very rare form of GM2 gangliosidosis due to a deficiency of GM2 activator protein. We report on two patients with typical clinical features suggestive of GM2 gangliosidosis, but normal results for hexosaminidase A and hexosaminidase B as...Pubmed

  • Change of the metabolomic profile during short-term mononuclear cell storage.

    Vox Sang. 2017;112(2): 163-172

    Steininger PA, Strasser EF, Ziehe B, Eckstein R, Rauh M

    BACKGROUND AND OBJECTIVES: Short-term storage of leukapheresis products used for immunotherapeutic mononuclear cell (MNC) products is a frequent event. The analysis of time-related metabolic patterns enables the characterization of storage-related effects in MNCs and the hypothesis-based...Pubmed

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