[Medication safety in children : What role do dosing and formulations play?]
Bundesgesundheitsblatt Gesundheitsforschung, Gesundheitsschutz. 2018;61(9): 1139-1145
Neubert A, Rascher W
Medication errors are more common in children compared to adults due to often missing efficacy evidence and limited or missing regulatory approvals for paediatric drugs.Roots of errors are located at different levels. They result, for example, from missing clinical studies that...Pubmed
A Comparison of GFR Estimation Formulae in Pediatric Oncology.
Klin Padiatr. 2018;230(3): 142-150
Rechenauer T, Zierk J, Gräfe D, Rascher W, Rauh M, Metzler M
BACKGROUND: Application of potentially nephrotoxic chemotherapy requires continuous monitoring of renal function for toxicity and dosing. Novel pediatric glomerular filtration rate (GFR) estimating equations including cystatin C have been proposed to enhance the reliability of GFR...Pubmed
Effects of Levetiracetam and Sulthiame on EEG in benign epilepsy with centrotemporal spikes: A randomized controlled trial.
Seizure. 2018;56(): 115-120
Tacke M, Borggraefe I, Gerstl L, Heinen F, Vill K, Bonfert M, Bast T, HEAD Study group , Neubauer BA, Baumeister F, Baethmann M, Bentele K, Blank C, Blank HM, Bode H, Bosch F, Brandl U, Brockmann K, Dahlem P, Ernst JP, Feldmann E, Fiedler A, Gerigk M, Heß S, Hikel C, Hoffmann HG, Kieslich M, Klepper J, Kluger G, Koch H...Pubmed
Genome-wide association study identifies multiple new loci associated with Ewing sarcoma susceptibility.
Nat Commun. 2018;9(1):
Machiela MJ, Grünewald TGP, Surdez D, Reynaud S, Mirabeau O, Karlins E, Rubio RA, Zaidi S, Grossetete-Lalami S, Ballet S, Lapouble E, Laurence V, Michon J, Pierron G, Kovar H, Gaspar N, Kontny U, González-Neira A, Picci P, Alonso J, Patino-Garcia A, Corradini N, Bérard PM, Freedman ND, Rothman N, Dagnall CL, Burdett L, Jones K, Manning M...Pubmed
Contrast-Enhanced µCT for Visualizing and Evaluating Murine Intestinal Inflammation.
Theranostics. 2018;8(22): 6357-6366
Jung D, Heiss R, Kramer V, Thoma OM, Regensburger AP, Rascher W, Uder M, Neurath MF, Knieling F, Waldner MJ
Rationale: To develop a simple and fast protocol for the assessment of acute and chronic experimental intestinal inflammation using contrast-enhanced µCT. Methods: For the imaging studies, an acute 2% and 3% dextran sodium sulfate...Pubmed
[Renal transplantation: Opportunities and risks for medical refugees].
Urologe A. 2018;57(10): 1200-1207
Mammadova D, Hirsch K, Schwaiger B, Wullich B, Rascher W
BACKGROUND: Families with children and adolescents with end-stage renal disease came to Germany from the former Eastern Bloc countries before the wave of refugees in 2015, in order to enable their children to survive with adequate kidney replacement therapy and in the best case a kidney...Pubmed
CTLA4 induction by Rhinovirus (RV) in pediatric asthma
Allergy. 2018;73(): 301-302
Koelle J, Haag P, Vuorinen T, Kiefer A, Zimmermann T, Papadopoulos NG, Finotto SPubmed
[Bilateral posterior persistent hyperplastic primary vitreous].
Ophthalmologe. 2018;115(8): 680-682
Hohberger B, Knorr HLJ, Mardin CY, Trollmann R, von Marchtaler P, Gusek-Schneider GC
Bilateral persistent hyperplastic primary vitreous (PHPV) represents a rare entity of a congential malformation. This casuistic presents for the first time in the German literature the case of a 4-month-old child with bilateral posterior PHPV.Pubmed
Rearrangement bursts generate canonical gene fusions in bone and soft tissue tumors.
Anderson ND, de Borja R, Young MD, Fuligni F, Rosic A, Roberts ND, Hajjar S, Layeghifard M, Novokmet A, Kowalski PE, Anaka M, Davidson S, Zarrei M, Id Said B, Schreiner LC, Marchand R, Sitter J, Gokgoz N, Brunga L, Graham GT, Fullam A, Pillay N, Toretsky JA, Yoshida A, Shibata T, Metzler M, Somers GR, Scherer SW, Flanagan AM, Campbell PJ, Schiffman JD, Shago M...Pubmed
Compound heterozygous RYR1 mutations in a preterm with arthrogryposis multiplex congenita and prenatal CNS bleeding.
Neuromuscul Disord. 2018;28(1): 54-58
Brackmann F, Türk M, Gratzki N, Rompel O, Jungbluth H, Schröder R, Trollmann R
RYR1 mutations, the most common cause of non-dystrophic neuromuscular disorders, are associated with the malignant hyperthermia susceptibility (MHS) trait as well as congenital myopathies with widely variable clinical and...Pubmed
Asymmetric Omphalopagus in a Triplet after In Vitro Fertilization: A Rare Case of Conjoined Twinning.
Case Rep Pediatr. 2018;2018():
Jabari S, Carbon R, Besendörfer M, Hartmann A, Rompel O, Hoerning A, Söder S
Introduction: Asymmetric omphalopagus is a rare situation of conjoined twinning, in which a grossly defective twin is attached to the thorax and upper abdomen of the main twin. We describe a case of an asymmetric omphalopagus accompanied by a normal...Pubmed
Influence of PCO2 Control on Clinical and Neurodevelopmental Outcomes of Extremely Low Birth Weight Infants.
Neonatology. 2018;113(3): 221-230
Thome UH, Dreyhaupt J, Genzel-Boroviczeny O, Bohnhorst B, Schmid M, Fuchs H, Rohde O, Avenarius S, Topf HG, Zimmermann A, Faas D, Timme K, Kleinlein B, Buxmann H, Schenk W, Segerer H, Teig N, Ackermann B, Hentschel R, Heckmann M, Schlösser R, Peters J, Rossi R, Rascher W, Böttger R, Seidenberg J, Hansen G, Bode H, Zernickel M...Pubmed
[Flight Routes to Germany of Seriously Ill Children and Adolescents From Former Eastern Bloc Countries for Treatment of Renal Failure].
Klin Padiatr. 2018;():
Mammadova D, Marek I, Galiano M, Rascher W
BACKGROUND: Increased patient mobility and restricted treatment of children with end-stage renal disease forced families from the former Eastern Bloc countries to flee with their children to Germany for adequate medical treatment. METHODS: In a case study, the...Pubmed
Medikamentenpriming am Beispiel der Therapie der Aufmerksamkeits-Defizit-Hyperaktivitäts-Störung (ADHS).
Drug Res (Stuttg). 2018;68(S 01): S25-S26
Front-line imatinib treatment in children and adolescents with chronic myeloid leukemia: results from a phase III trial.
Leukemia. 2018;32(7): 1657-1669
Suttorp M, Schulze P, Glauche I, Göhring G, von Neuhoff N, Metzler M, Sedlacek P, de Bont ESJM, Balduzzi A, Lausen B, Aleinikova O, Sufliarska S, Henze G, Strauss G, Eggert A, Kremens B, Groll AH, Berthold F, Klein C, Groß-Wieltsch U, Sykora KW, Borkhardt A, Kulozik AE, Schrappe M, Nowasz C, Krumbholz M, Tauer JT, Claviez...Pubmed
Histopathological proof of the pathogenicity of a rare GFAP mutation in a patient with flaccid paraparesis.
Brain Dev. 2018;40(4): 330-333
Brackmann F, Coras R, Rössler K, Kraus C, Rompel O, Trollmann R
Infantile Alexander disease is a rare progressive leukodystrophy caused by autosomal dominant mutations in the (GFAP) gene typically presenting with psychomotor retardation, progressive macrocephaly and refractory epilepsy. Neuroradiological hallmarks are...Pubmed
Idiopathic Mast Cell Activation Syndrome With Associated Salicylate Intolerance.
Front Pediatr. 2018;6():
Rechenauer T, Raithel M, Götze T, Siebenlist G, Rückel A, Baenkler HW, Hartmann A, Haller F, Hoerning A
Idiopathic mast cell activation syndrome can be a rare cause for chronic abdominal pain in children. It remains a diagnosis by exclusion that can be particularly challenging due to the vast variety of possible clinical manifestations. We present a...Pubmed
Influence of factor XIII activity on post-operative transfusion in congenital cardiac surgery-A retrospective analysis.
PLoS ONE. 2018;13(7):
Fahlbusch FB, Heinlein T, Rauh M, Dittrich S, Cesnjevar R, Moosmann J, Nadal J, Schmid M, Muench F, Schroth M, Rascher W, Topf HG
OBJECTIVES: Coagulation factor XIII (FXIII) plays a key role in fibrin clot stabilization-an essential process for wound healing following cardiothoracic surgery. However, FXIII deficiency as a...Pubmed
Expression of the Alpha8 Integrin Chain Facilitates Phagocytosis by Renal Mesangial Cells.
Cell Physiol Biochem. 2018;45(6): 2161-2173
Marek I, Becker R, Fahlbusch FB, Menendez-Castro C, Rascher W, Daniel C, Volkert G, Hartner A
BACKGROUND/AIMS: Healing of mesangioproliferative glomerulonephritis involves degradation of excess extracellular matrix, resolution of hypercellularity by apoptosis and phagocytosis of apoptotic cells. Integrin receptors participate in...Pubmed
Low-Frequency Stimulation of Silent Nociceptors Induces Secondary Mechanical Hyperalgesia in Human Skin.
Neuroscience. 2018;387(): 4-12
Sauerstein K, Liebelt J, Namer B, Schmidt R, Rukwied R, Schmelz M
Secondary mechanical hyperalgesia to punctate mechanical stimuli and light touch (allodynia) are prominent symptoms in neuropathic pain states. In a combined microneurographic and psychophysical study, we investigated the role of mechano-insensitive (silent...Pubmed
Effect of maternal smoking on stress physiology in healthy neonates.
J Perinatol. 2018;38(2): 132-136
Haslinger C, Bamert H, Rauh M, Burkhardt T, Schäffer L
OBJECTIVE: To assess the impact of maternal smoking during pregnancy (MSDP) on the neonatal hypothalamic-pituitary-adrenal axis. STUDY DESIGN: In a prospective observational study, salivary cortisol and cortisone levels were measured at the fourth day of life during resting conditions and in response to...Pubmed
Generic formulations of imatinib for treatment of Philadelphia chromosome-positive leukemia in pediatric patients.
Pediatr Blood Cancer. 2018;65(12):
Suttorp M, Metzler M, Millot F, Shimada H, Bansal D, Günes AM, Kalwak K, Sedlacek P, Baruchel A, Biondi A, Hijiya N, Schultz KR, Schrappe M
Since the patent for imatinib has expired, the role of generic imatinib (GI) in the management of Philadelphia chromosome-positive (Ph+) leukemia in pediatric patients has...Pubmed
Differential regulation of angiogenesis in the developing mouse brain in response to exogenous activation of the hypoxia-inducible transcription factor system.
Brain Res. 2018;1688(): 91-102
Trollmann R, Mühlberger T, Richter M, Boie G, Feigenspan A, Brackmann F, Jung S
Angiogenesis due to hypoxic-ischemic (HI) injury represents a crucial compensatory mechanism of the developing brain that is mainly regulated by hypoxia-inducible transcription factors (HIF...Pubmed
Low incidence of symptomatic osteonecrosis after allogeneic HSCT in children with high-risk or relapsed ALL - results of the ALL-SCT 2003 trial.
Br J Haematol. 2018;183(1): 104-109
Kuhlen M, Bader P, Sauer M, Albert MH, Gruhn B, Güngör T, Kropshofer G, Lang P, Lawitschka A, Metzler M, Pentek F, Rossig C, Schlegel PG, Schrappe M, Schrum J, Schulz A, Schwinger W, von Stackelberg A, Strahm B, Suttorp M, Luettichau IT, Wößmann W, Borkhardt A, Meisel R, Poetschger U, Glogova...Pubmed
Prenatal Correction of X-Linked Hypohidrotic Ectodermal Dysplasia.
N Engl J Med. 2018;378(17): 1604-1610
Schneider H, Faschingbauer F, Schuepbach-Mallepell S, Körber I, Wohlfart S, Dick A, Wahlbuhl M, Kowalczyk-Quintas C, Vigolo M, Kirby N, Tannert C, Rompel O, Rascher W, Beckmann MW, Schneider P
Genetic deficiency of ectodysplasin A (EDA) causes X-linked hypohidrotic ectodermal dysplasia (XLHED), in which the development of sweat glands is irreversibly...Pubmed
Neurological outcome at 24 months corrected age of prematurely born infants after preterm premature rupture of membranes (PPROM) of at least 7 days: a two-center experience in Germany.
J Matern Fetal Neonatal Med. 2018;(): 1-6
Müller H, Storbeck T, Katzer D, Bruns N, Wössner-Stegmann G, Ai M, Köninger A, Müller A, Felderhoff-Müser U, Bagci S
OBJECTIVE: Preterm premature rupture of membranes (PPROM) is a risk factor for chorioamnionitis (CA) and injury to...Pubmed
Pharmacology and pharmacokinetics of imatinib in pediatric patients.
Expert Rev Clin Pharmacol. 2018;11(3): 219-231
Suttorp M, Bornhäuser M, Metzler M, Millot F, Schleyer E
INTRODUCTION: The tyrosine kinase inhibitor (TKI) imatinib was rationally designed to target BCR-ABL1 which is constitutively activated in chronic myeloid leukemia (CML). Following the tremendous success in adults, imatinib also became licensed for treatment of CML in minors. The rarity...Pubmed
Indirect determination of hematology reference intervals in adult patients on Beckman Coulter UniCell DxH 800 and Abbott CELL-DYN Sapphire devices.
Clin Chem Lab Med. 2018;():
Zierk J, Arzideh F, Haeckel R, Rauh M, Metzler M, Ganslandt T, Krause SW
Background Conventional establishment of reference intervals for hematological analytes is challenging due to the need to recruit healthy persons. Indirect methods address this by deriving reference intervals from...Pubmed
Dynamic reference intervals for coagulation parameters from infancy to adolescence.
Clin Chim Acta. 2018;482(): 124-135
Weidhofer C, Meyer E, Ristl R, Wiedemann H, Cadamuro J, Kipman U, Zierk J, Male C, Quehenberger P, Haschke-Becher E, Einwallner E
INTRODUCTION: Practical and ethical challenges as well as time and costs have restricted the generation of pediatric reference intervals. Therefore, pediatric reference intervals on coagulation parameters based on...Pubmed
Serum (1→3)-β-D-glucan and galactomannan levels in patients with cystic fibrosis: a retrospective cohort study.
BMC Pulm Med. 2018;18(1):
Träger J, Melichar VO, Meyer R, Rauh M, Bogdan C, Held J
BACKGROUND: Aspergillus fumigatus is frequently encountered in sputum samples of patients with cystic fibrosis (CF), which traditionally has been interpreted as saprophytic airway colonization. However, this mere bystander role has been challenged by recent data...Pubmed