Perinatal hypoxic brain injury and neuroprotection

Paediatrics

Head of Department:
Prof. Dr. med. Joachim Wölfle

Perinatal hypoxic brain injury and neuroprotection

Aiming at an early detection and prevention of perinatal brain injury caused by acute or chronic hypoxia, we have been analyzing the regulation and function of hypoxia-inducible transcription factors (HIF) in the immature brain. HIF-regulated factors with strong impact on the adaptation to hypoxic conditions have been characterized as placental indicators of severe hypoxic-ischemic CNS injury in term neonates. In a mouse model of perinatal brain hypoxia, gestational age-dependent and cell-specific molecular effects of hypoxia on endogenous neuroprotective mechanisms have been demonstrated. Furthermore, the impact of perinatal hypoxia on early neuronal migration, astrocytic, and blood-brain barrier function has been investigated - as well as experimental approaches to stabilize HIF by pharmacological means.

 
Project manager
Collaborators

Gudrun Boie, VMTA

Telefon: 0049-(0)9131 85-40134

Stephanie Palffy, MTA

Telefon: 0049-(0)9131 85-40132

Elke Schirmer, MTA

Telefon: 0049-(0)9131 85-36222