Differentiation pathways during skeletal development

Paediatrics

Head of Department:
Prof. Dr. med. Joachim Wölfle

Differentiation pathways during skeletal development

To clarify the origin of osteoprogenitor cells and the role of certain signaling molecules during skeletal development, we have been using a broad spectrum of methods including immunohistochemical approaches, gene expression assays, special cell culture systems, and determination of various enzyme activities by mass spectrometry. A related research project is focused on the controlled differentiation of cord blood-derived mesenchymal stem cells into osteoblasts and chondrocytes. These cells could be used for autografts, e.g. in the treatment of cleft lip and palate (the most common congenital malformation) to reduce the number of surgical interventions required.

 

 
Project managers